Amifostine Suppresses the Side Effects of Radiation on BMSCs by Promoting Cell Proliferation and Reducing ROS Production
المؤلفون المشاركون
Huang, Bo
Gong, Ping
Tang, Hua
Yao, Qianqian
Zhang, Liang
Yao, Yang
He, Tao
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-01-09
دولة النشر
مصر
عدد الصفحات
14
الملخص EN
This study is aimed at investigating the effect of amifostine (AMI) on rat bone marrow stromal stem cells (BMSCs) exposed to 2 Gy radiation.
The BMSCs were divided into four groups, namely, group A that received 0 Gy radiation, group B that received 0 Gy radiation and AMI, group C that received 2 Gy radiation, and group D that received 2 Gy radiation and AMI.
The proliferation, apoptosis, and distribution of BMSCs in the cell cycle, along with their osteogenesis ability, adipogenesis ability, and ROS production, were subsequently examined.
The levels of ALP, PPARγ, P53, and TNFα were determined by Western blotting.
The results demonstrated that the proliferation of BMSCs and the levels of ALP in group C were much lower than those in group A.
The production of ROS and levels of PPARγ, P53, and TNFα in the group that received 2 Gy radiation were much higher than those in group A.
Furthermore, the production of ROS and the levels of PPARγ, P53, and TNFα were much lower in group D than in group C.
Additionally, the levels of ALP and extent of cell proliferation were much higher in group D than in group C.
The results demonstrated the potential of AMI in reducing the side effects of radiation in BMSCs and in treatment of bone diseases caused by radiation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Huang, Bo& He, Tao& Yao, Qianqian& Zhang, Liang& Tang, Hua& Gong, Ping…[et al.]. 2019. Amifostine Suppresses the Side Effects of Radiation on BMSCs by Promoting Cell Proliferation and Reducing ROS Production. Stem Cells International،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1209830
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tang, Hua…[et al.]. Amifostine Suppresses the Side Effects of Radiation on BMSCs by Promoting Cell Proliferation and Reducing ROS Production. Stem Cells International No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1209830
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Huang, Bo& He, Tao& Yao, Qianqian& Zhang, Liang& Tang, Hua& Gong, Ping…[et al.]. Amifostine Suppresses the Side Effects of Radiation on BMSCs by Promoting Cell Proliferation and Reducing ROS Production. Stem Cells International. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1209830
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1209830
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر