Multiple Sclerosis Patients with Markedly Low Intrathecal Antibody Response in Sri Lanka
المؤلفون المشاركون
Gamage, S. M. K.
Wijeweera, I.
Adikari, S. B.
Fink, Katharina
Hillert, Jan
Fogdell-Hahn, Anna
Sominanda, H. M. A.
المصدر
Multiple Sclerosis International
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-02-28
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Multiple sclerosis (MS) is a heterogeneous disease which is poorly studied in Asia, where the disease is known to be rare with significant differences in clinical and radiological presentations and intrathecal antibody response.
Therefore the objective of this study was to determine clinical presentation, radiological and neurophysiological characteristics, and oligoclonal band status in Sri Lankan MS patients, following careful exclusion of patients with neuromyelitis optica spectrum disorders and other conditions mimicking multiple sclerosis.
Sixty-nine MS patients were recruited to the study adhering to McDonald 2010 criteria.
Their clinical presentation, characteristics of central nervous system lesions in magnetic resonance imaging, visual evoked potential (VEP) results, oligoclonal bands (OCB), and AQP4 antibody status were studied.
Of 69 MS patients, 54%, 6%, and 1% were relapsing remitting, secondary progressive, and primary progressive, respectively, and 39% were patients with clinically isolated syndrome.
The commonest clinical presentations were cerebral motor followed by cerebral sensory and optic neuritis.
Majority had typical periventricular and infratentorial lesions in MRI.
Though not clinically apparent, bilateral delay of P100 wave latency was present in 52%.
OCB positivity was 42% and AQP4 antibody was positive in only one patient.
In conclusion, this group of Sri Lankan MS patients shares most of the clinical and radiological features of Caucasian MS patients.
However, the OCB positivity is lower in this group, when compared to the Caucasian MS populations.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gamage, S. M. K.& Wijeweera, I.& Adikari, S. B.& Fink, Katharina& Hillert, Jan& Fogdell-Hahn, Anna…[et al.]. 2018. Multiple Sclerosis Patients with Markedly Low Intrathecal Antibody Response in Sri Lanka. Multiple Sclerosis International،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1209864
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gamage, S. M. K.…[et al.]. Multiple Sclerosis Patients with Markedly Low Intrathecal Antibody Response in Sri Lanka. Multiple Sclerosis International No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1209864
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gamage, S. M. K.& Wijeweera, I.& Adikari, S. B.& Fink, Katharina& Hillert, Jan& Fogdell-Hahn, Anna…[et al.]. Multiple Sclerosis Patients with Markedly Low Intrathecal Antibody Response in Sri Lanka. Multiple Sclerosis International. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1209864
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1209864
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر