Multiple Sclerosis Patients with Markedly Low Intrathecal Antibody Response in Sri Lanka
Joint Authors
Gamage, S. M. K.
Wijeweera, I.
Adikari, S. B.
Fink, Katharina
Hillert, Jan
Fogdell-Hahn, Anna
Sominanda, H. M. A.
Source
Multiple Sclerosis International
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Multiple sclerosis (MS) is a heterogeneous disease which is poorly studied in Asia, where the disease is known to be rare with significant differences in clinical and radiological presentations and intrathecal antibody response.
Therefore the objective of this study was to determine clinical presentation, radiological and neurophysiological characteristics, and oligoclonal band status in Sri Lankan MS patients, following careful exclusion of patients with neuromyelitis optica spectrum disorders and other conditions mimicking multiple sclerosis.
Sixty-nine MS patients were recruited to the study adhering to McDonald 2010 criteria.
Their clinical presentation, characteristics of central nervous system lesions in magnetic resonance imaging, visual evoked potential (VEP) results, oligoclonal bands (OCB), and AQP4 antibody status were studied.
Of 69 MS patients, 54%, 6%, and 1% were relapsing remitting, secondary progressive, and primary progressive, respectively, and 39% were patients with clinically isolated syndrome.
The commonest clinical presentations were cerebral motor followed by cerebral sensory and optic neuritis.
Majority had typical periventricular and infratentorial lesions in MRI.
Though not clinically apparent, bilateral delay of P100 wave latency was present in 52%.
OCB positivity was 42% and AQP4 antibody was positive in only one patient.
In conclusion, this group of Sri Lankan MS patients shares most of the clinical and radiological features of Caucasian MS patients.
However, the OCB positivity is lower in this group, when compared to the Caucasian MS populations.
American Psychological Association (APA)
Gamage, S. M. K.& Wijeweera, I.& Adikari, S. B.& Fink, Katharina& Hillert, Jan& Fogdell-Hahn, Anna…[et al.]. 2018. Multiple Sclerosis Patients with Markedly Low Intrathecal Antibody Response in Sri Lanka. Multiple Sclerosis International،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1209864
Modern Language Association (MLA)
Gamage, S. M. K.…[et al.]. Multiple Sclerosis Patients with Markedly Low Intrathecal Antibody Response in Sri Lanka. Multiple Sclerosis International No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1209864
American Medical Association (AMA)
Gamage, S. M. K.& Wijeweera, I.& Adikari, S. B.& Fink, Katharina& Hillert, Jan& Fogdell-Hahn, Anna…[et al.]. Multiple Sclerosis Patients with Markedly Low Intrathecal Antibody Response in Sri Lanka. Multiple Sclerosis International. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1209864
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1209864