IL-10 Gene-Modified Human Amniotic Mesenchymal Stem Cells Augment Regenerative Wound Healing by Multiple Synergistic Effects

المؤلفون المشاركون

Xiao, Shune
Wei, Zairong
Deng, Chengliang
Nie, Kaiyu
Wang, Dali
Liu, Zhiyuan
Huang, Guangtao

المصدر

Stem Cells International

العدد

المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-13، 13ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2019-06-11

دولة النشر

مصر

عدد الصفحات

13

الملخص EN

Mesenchymal stem cells (MSCs) possess a capacity to enhance cutaneous wound healing that is well characterized.

However, the therapeutic effect of MSCs appears to be limited.

Modifying MSC target genes to increase necessary biological effects is a promising strategy for wound therapy.

Interleukin-10 (IL-10) is an anti-inflammatory cytokine that has a therapeutic effect on wound healing.

In this study, we modified human amniotic mesenchymal stem cells (hAMSCs) using recombinant lentiviral vectors for expressing IL-10 and evaluated the therapeutic effects of hAMSCs-IL-10 in wound healing.

We elucidated the mechanisms underlying the effects.

We found that promoting wound healing was maintained by synergistic effects of hAMSCs and IL-10.

hAMSCs-IL-10 showed stronger biological effects in accelerating wound closure, enhancing angiogenesis, modulating inflammation, and regulating extracellular matrix remodeling than hAMSCs.

hAMSCs-IL-10 would be better at promoting wound healing and improving healing quality.

These data may provide a theoretical foundation for clinical administration of hAMSCs-IL-10 in cutaneous wound healing and skin regeneration.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Xiao, Shune& Huang, Guangtao& Wei, Zairong& Nie, Kaiyu& Liu, Zhiyuan& Deng, Chengliang…[et al.]. 2019. IL-10 Gene-Modified Human Amniotic Mesenchymal Stem Cells Augment Regenerative Wound Healing by Multiple Synergistic Effects. Stem Cells International،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1209919

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Xiao, Shune…[et al.]. IL-10 Gene-Modified Human Amniotic Mesenchymal Stem Cells Augment Regenerative Wound Healing by Multiple Synergistic Effects. Stem Cells International No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1209919

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Xiao, Shune& Huang, Guangtao& Wei, Zairong& Nie, Kaiyu& Liu, Zhiyuan& Deng, Chengliang…[et al.]. IL-10 Gene-Modified Human Amniotic Mesenchymal Stem Cells Augment Regenerative Wound Healing by Multiple Synergistic Effects. Stem Cells International. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1209919

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1209919