IL-10 Gene-Modified Human Amniotic Mesenchymal Stem Cells Augment Regenerative Wound Healing by Multiple Synergistic Effects
Joint Authors
Xiao, Shune
Wei, Zairong
Deng, Chengliang
Nie, Kaiyu
Wang, Dali
Liu, Zhiyuan
Huang, Guangtao
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-11
Country of Publication
Egypt
No. of Pages
13
Abstract EN
Mesenchymal stem cells (MSCs) possess a capacity to enhance cutaneous wound healing that is well characterized.
However, the therapeutic effect of MSCs appears to be limited.
Modifying MSC target genes to increase necessary biological effects is a promising strategy for wound therapy.
Interleukin-10 (IL-10) is an anti-inflammatory cytokine that has a therapeutic effect on wound healing.
In this study, we modified human amniotic mesenchymal stem cells (hAMSCs) using recombinant lentiviral vectors for expressing IL-10 and evaluated the therapeutic effects of hAMSCs-IL-10 in wound healing.
We elucidated the mechanisms underlying the effects.
We found that promoting wound healing was maintained by synergistic effects of hAMSCs and IL-10.
hAMSCs-IL-10 showed stronger biological effects in accelerating wound closure, enhancing angiogenesis, modulating inflammation, and regulating extracellular matrix remodeling than hAMSCs.
hAMSCs-IL-10 would be better at promoting wound healing and improving healing quality.
These data may provide a theoretical foundation for clinical administration of hAMSCs-IL-10 in cutaneous wound healing and skin regeneration.
American Psychological Association (APA)
Xiao, Shune& Huang, Guangtao& Wei, Zairong& Nie, Kaiyu& Liu, Zhiyuan& Deng, Chengliang…[et al.]. 2019. IL-10 Gene-Modified Human Amniotic Mesenchymal Stem Cells Augment Regenerative Wound Healing by Multiple Synergistic Effects. Stem Cells International،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1209919
Modern Language Association (MLA)
Xiao, Shune…[et al.]. IL-10 Gene-Modified Human Amniotic Mesenchymal Stem Cells Augment Regenerative Wound Healing by Multiple Synergistic Effects. Stem Cells International No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1209919
American Medical Association (AMA)
Xiao, Shune& Huang, Guangtao& Wei, Zairong& Nie, Kaiyu& Liu, Zhiyuan& Deng, Chengliang…[et al.]. IL-10 Gene-Modified Human Amniotic Mesenchymal Stem Cells Augment Regenerative Wound Healing by Multiple Synergistic Effects. Stem Cells International. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1209919
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1209919