Effects of Antipsychotic Drugs on the Epigenetic Modification of Brain-Derived Neurotrophic Factor Gene Expression in the Hippocampi of Chronic Restraint Stress Rats
المؤلفون المشاركون
McIntyre, Roger S.
Seo, Mi Kyoung
Kim, Young Hoon
Mansur, Rodrigo B.
Lee, Yena
Carmona, Nicole E.
Choi, Ah Jeong
Kim, Gyung-Mee
Lee, Jung Goo
Park, Sung Woo
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-06-11
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Recent studies have shown that antipsychotic drugs have epigenetic effects.
However, the effects of antipsychotic drugs on histone modification remain unclear.
Therefore, we investigated the effects of antipsychotic drugs on the epigenetic modification of the BDNF gene in the rat hippocampus.
Rats were subjected to chronic restraint stress (6 h/d for 21 d) and then were administered with either olanzapine (2 mg/kg) or haloperidol (1 mg/kg).
The levels of histone H3 acetylation and MeCP2 binding at BDNF promoter IV were assessed with chromatin immunoprecipitation assays.
The mRNA levels of total BDNF with exon IV, HDAC5, DNMT1, and DNMT3a were assessed with a quantitative RT-PCR procedure.
Chronic restraint stress resulted in the downregulation of total and exon IV BDNF mRNA levels and a decrease in histone H3 acetylation and an increase in MeCP2 binding at BDNF promoter IV.
Furthermore, there were robust increases in the expression of HDAC5 and DNMTs.
Olanzapine administration largely prevented these changes.
The administration of haloperidol had no effect.
These findings suggest that the antipsychotic drug olanzapine induced histone modification of BDNF gene expression in the hippocampus and that these epigenetic alterations may represent one of the mechanisms underlying the actions of antipsychotic drugs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Seo, Mi Kyoung& Kim, Young Hoon& McIntyre, Roger S.& Mansur, Rodrigo B.& Lee, Yena& Carmona, Nicole E.…[et al.]. 2018. Effects of Antipsychotic Drugs on the Epigenetic Modification of Brain-Derived Neurotrophic Factor Gene Expression in the Hippocampi of Chronic Restraint Stress Rats. Neural Plasticity،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1209997
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Seo, Mi Kyoung…[et al.]. Effects of Antipsychotic Drugs on the Epigenetic Modification of Brain-Derived Neurotrophic Factor Gene Expression in the Hippocampi of Chronic Restraint Stress Rats. Neural Plasticity No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1209997
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Seo, Mi Kyoung& Kim, Young Hoon& McIntyre, Roger S.& Mansur, Rodrigo B.& Lee, Yena& Carmona, Nicole E.…[et al.]. Effects of Antipsychotic Drugs on the Epigenetic Modification of Brain-Derived Neurotrophic Factor Gene Expression in the Hippocampi of Chronic Restraint Stress Rats. Neural Plasticity. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1209997
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1209997
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر