Effects of Antipsychotic Drugs on the Epigenetic Modification of Brain-Derived Neurotrophic Factor Gene Expression in the Hippocampi of Chronic Restraint Stress Rats
Joint Authors
McIntyre, Roger S.
Seo, Mi Kyoung
Kim, Young Hoon
Mansur, Rodrigo B.
Lee, Yena
Carmona, Nicole E.
Choi, Ah Jeong
Kim, Gyung-Mee
Lee, Jung Goo
Park, Sung Woo
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-11
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Recent studies have shown that antipsychotic drugs have epigenetic effects.
However, the effects of antipsychotic drugs on histone modification remain unclear.
Therefore, we investigated the effects of antipsychotic drugs on the epigenetic modification of the BDNF gene in the rat hippocampus.
Rats were subjected to chronic restraint stress (6 h/d for 21 d) and then were administered with either olanzapine (2 mg/kg) or haloperidol (1 mg/kg).
The levels of histone H3 acetylation and MeCP2 binding at BDNF promoter IV were assessed with chromatin immunoprecipitation assays.
The mRNA levels of total BDNF with exon IV, HDAC5, DNMT1, and DNMT3a were assessed with a quantitative RT-PCR procedure.
Chronic restraint stress resulted in the downregulation of total and exon IV BDNF mRNA levels and a decrease in histone H3 acetylation and an increase in MeCP2 binding at BDNF promoter IV.
Furthermore, there were robust increases in the expression of HDAC5 and DNMTs.
Olanzapine administration largely prevented these changes.
The administration of haloperidol had no effect.
These findings suggest that the antipsychotic drug olanzapine induced histone modification of BDNF gene expression in the hippocampus and that these epigenetic alterations may represent one of the mechanisms underlying the actions of antipsychotic drugs.
American Psychological Association (APA)
Seo, Mi Kyoung& Kim, Young Hoon& McIntyre, Roger S.& Mansur, Rodrigo B.& Lee, Yena& Carmona, Nicole E.…[et al.]. 2018. Effects of Antipsychotic Drugs on the Epigenetic Modification of Brain-Derived Neurotrophic Factor Gene Expression in the Hippocampi of Chronic Restraint Stress Rats. Neural Plasticity،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1209997
Modern Language Association (MLA)
Seo, Mi Kyoung…[et al.]. Effects of Antipsychotic Drugs on the Epigenetic Modification of Brain-Derived Neurotrophic Factor Gene Expression in the Hippocampi of Chronic Restraint Stress Rats. Neural Plasticity No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1209997
American Medical Association (AMA)
Seo, Mi Kyoung& Kim, Young Hoon& McIntyre, Roger S.& Mansur, Rodrigo B.& Lee, Yena& Carmona, Nicole E.…[et al.]. Effects of Antipsychotic Drugs on the Epigenetic Modification of Brain-Derived Neurotrophic Factor Gene Expression in the Hippocampi of Chronic Restraint Stress Rats. Neural Plasticity. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1209997
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1209997