Mesenchymal Stem Cells Coated by the Extracellular Matrix Promote Wound Healing in Diabetic Rats
المؤلفون المشاركون
Zhao, Liling
Wan, Xin-xing
Mo, Zhaohui
Wang, Fang
Yue, Chun
Wang, Linhao
Yang, Wenjun
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-01-28
دولة النشر
مصر
عدد الصفحات
7
الملخص EN
Objective.
To investigate the effects of mesenchymal stem cells (MSCs) coated by the extracellular matrix (ECM) on wound healing in diabetic rats.
Methods.
Mesenchymal stem cells were cocultured with ECM.
Cell viabilities were evaluated using MTT assay.
The diabetes model was established using both STZ and high-glucose/fat methods in SD rats.
A wound area was made on the middle of the rats’ back.
MSCs or ECM-MSCs were used to treat the rats.
HE staining and CD31 immunohistochemistry were used to detect the skin thickness and angiogenesis.
Western blotting and qRT-PCR were conducted to determine the level of VEGF-α, PDGF, and EGF.
Results.
It was observed that treatment of ECM had no significant effects on the cell viability of ECM-MSCs.
Wound area assay showed that both MSCs and ECM-MSCs could enhance the wound healing of diabetic rats and ECM-MSCs could further promote the effects.
Both MSCs and ECM-MSCs could enhance angiogenesis and epithelialization of the wounds, as well as the expression of VEGF-α, PDGF, and EGF in wound tissues, while ECM-MSC treatment showed more obvious effects.
Conclusion.
Mesenchymal stem cells coated by the extracellular matrix could promote wound healing in diabetic rats.
Our study may offer a novel therapeutic method for impaired diabetic wound healing.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Linhao& Wang, Fang& Zhao, Liling& Yang, Wenjun& Wan, Xin-xing& Yue, Chun…[et al.]. 2019. Mesenchymal Stem Cells Coated by the Extracellular Matrix Promote Wound Healing in Diabetic Rats. Stem Cells International،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1210018
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Linhao…[et al.]. Mesenchymal Stem Cells Coated by the Extracellular Matrix Promote Wound Healing in Diabetic Rats. Stem Cells International No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1210018
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Linhao& Wang, Fang& Zhao, Liling& Yang, Wenjun& Wan, Xin-xing& Yue, Chun…[et al.]. Mesenchymal Stem Cells Coated by the Extracellular Matrix Promote Wound Healing in Diabetic Rats. Stem Cells International. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1210018
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1210018
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر