N-Methyl-D-Aspartate Receptors Involvement in the Gentamicin-Induced Hearing Loss and Pathological Changes of Ribbon Synapse in the Mouse Cochlear Inner Hair Cells
المؤلفون المشاركون
Li, Huawei
Yang, Lin
Hong, Juan
Chen, Yan
Zhang, Yanping
Li, Jieying
Ren, Liujie
Shi, Lusen
Li, Ao
Zhang, Tianyu
Dai, Peidong
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-07-15
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Cochlear inner hair cell (IHC) ribbon synapses play an important role in sound encoding and neurotransmitter release.
Previous reports show that both noise and aminoglycoside exposures lead to reduced numbers and morphologic changes of synaptic ribbons.
In this work, we determined the distribution of N-methyl-D-aspartate receptors (NMDARs) and their role in the gentamicin-induced pathological changes of cochlear IHC ribbon synaptic elements.
In normal mature mouse cochleae, the majority of NMDARs were distributed on the modiolar side of IHCs and close to the IHC nuclei region, while most of synaptic ribbons and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) were located on neural terminals closer to the IHC basal poles.
After gentamicin exposure, the NMDARs increased and moved towards the IHC basal poles.
At the same time, synaptic ribbons and AMPARs moved toward the IHC bundle poles on the afferent dendrites.
The number of ribbon synapse decreased, and this was accompanied by increased auditory brainstem response thresholds and reduced wave I amplitudes.
NMDAR antagonist MK801 treatment reduced the gentamicin-induced hearing loss and the pathological changes of IHC ribbon synapse, suggesting that NMDARs were involved in gentamicin-induced ototoxicity by regulating the number and distribution of IHC ribbon synapses.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hong, Juan& Chen, Yan& Zhang, Yanping& Li, Jieying& Ren, Liujie& Yang, Lin…[et al.]. 2018. N-Methyl-D-Aspartate Receptors Involvement in the Gentamicin-Induced Hearing Loss and Pathological Changes of Ribbon Synapse in the Mouse Cochlear Inner Hair Cells. Neural Plasticity،Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1210064
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hong, Juan…[et al.]. N-Methyl-D-Aspartate Receptors Involvement in the Gentamicin-Induced Hearing Loss and Pathological Changes of Ribbon Synapse in the Mouse Cochlear Inner Hair Cells. Neural Plasticity No. 2018 (2018), pp.1-16.
https://search.emarefa.net/detail/BIM-1210064
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hong, Juan& Chen, Yan& Zhang, Yanping& Li, Jieying& Ren, Liujie& Yang, Lin…[et al.]. N-Methyl-D-Aspartate Receptors Involvement in the Gentamicin-Induced Hearing Loss and Pathological Changes of Ribbon Synapse in the Mouse Cochlear Inner Hair Cells. Neural Plasticity. 2018. Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1210064
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1210064
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر