N-Methyl-D-Aspartate Receptors Involvement in the Gentamicin-Induced Hearing Loss and Pathological Changes of Ribbon Synapse in the Mouse Cochlear Inner Hair Cells
Joint Authors
Li, Huawei
Yang, Lin
Hong, Juan
Chen, Yan
Zhang, Yanping
Li, Jieying
Ren, Liujie
Shi, Lusen
Li, Ao
Zhang, Tianyu
Dai, Peidong
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-15
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Cochlear inner hair cell (IHC) ribbon synapses play an important role in sound encoding and neurotransmitter release.
Previous reports show that both noise and aminoglycoside exposures lead to reduced numbers and morphologic changes of synaptic ribbons.
In this work, we determined the distribution of N-methyl-D-aspartate receptors (NMDARs) and their role in the gentamicin-induced pathological changes of cochlear IHC ribbon synaptic elements.
In normal mature mouse cochleae, the majority of NMDARs were distributed on the modiolar side of IHCs and close to the IHC nuclei region, while most of synaptic ribbons and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) were located on neural terminals closer to the IHC basal poles.
After gentamicin exposure, the NMDARs increased and moved towards the IHC basal poles.
At the same time, synaptic ribbons and AMPARs moved toward the IHC bundle poles on the afferent dendrites.
The number of ribbon synapse decreased, and this was accompanied by increased auditory brainstem response thresholds and reduced wave I amplitudes.
NMDAR antagonist MK801 treatment reduced the gentamicin-induced hearing loss and the pathological changes of IHC ribbon synapse, suggesting that NMDARs were involved in gentamicin-induced ototoxicity by regulating the number and distribution of IHC ribbon synapses.
American Psychological Association (APA)
Hong, Juan& Chen, Yan& Zhang, Yanping& Li, Jieying& Ren, Liujie& Yang, Lin…[et al.]. 2018. N-Methyl-D-Aspartate Receptors Involvement in the Gentamicin-Induced Hearing Loss and Pathological Changes of Ribbon Synapse in the Mouse Cochlear Inner Hair Cells. Neural Plasticity،Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1210064
Modern Language Association (MLA)
Hong, Juan…[et al.]. N-Methyl-D-Aspartate Receptors Involvement in the Gentamicin-Induced Hearing Loss and Pathological Changes of Ribbon Synapse in the Mouse Cochlear Inner Hair Cells. Neural Plasticity No. 2018 (2018), pp.1-16.
https://search.emarefa.net/detail/BIM-1210064
American Medical Association (AMA)
Hong, Juan& Chen, Yan& Zhang, Yanping& Li, Jieying& Ren, Liujie& Yang, Lin…[et al.]. N-Methyl-D-Aspartate Receptors Involvement in the Gentamicin-Induced Hearing Loss and Pathological Changes of Ribbon Synapse in the Mouse Cochlear Inner Hair Cells. Neural Plasticity. 2018. Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1210064
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1210064