Pirt Together with TRPV1 Is Involved in the Regulation of Neuropathic Pain
المؤلفون المشاركون
Yu, Guang
Wang, Changming
Yang, Yan
Yu, Lei
Gu, Leying
Ruan, Yonglan
Gegen, Tana
Zhu, Chan
Zhou, Yuan
Tang, Zongxiang
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-04-02
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Neuropathic pain is a chronic pain and reduces the life quality of patients substantially.
Transient receptor potential vanilloid channel 1 (TRPV1), a nonselective cation channel, has been shown to play a crucial role in neuropathic pain.
Although TRPV1 plays an important role in neuropathic pain, the mechanism of how TRPV1 was regulated in neuropathic pain remains unclear.
Pirt is a membrane protein and binds to TRPV1 to enhance its activity.
It was suggested that Pirt should also be involved in neuropathic pain.
In this study, we investigated the role of Pirt in neuropathic pain (CCI model); the results show that mechanical allodynia and thermal hyperalgesia were alleviated in Pirt−/− mice in CCI models.
TRPV1 expression was increased by immunofluorescence and real-time PCR experiments.
The increase in TRPV1 expression was less in Pirt knockout mice in CCI models.
Moreover, the number of capsaicin-responding neurons and the magnitude of evoked calcium response were attenuated in DRG neurons from Pirt−/− mice in CCI models.
Finally, we found that the pain behavior attenuated in dysfunction of both Pirt and TRPV1 was much stronger than in dysfunction of Pirt or TRPV1 only in a CCI model in vitro study.
Taken together, Pirt together with TRPV1 is involved in CCI-induced neuropathic pain.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Changming& Gu, Leying& Ruan, Yonglan& Gegen, Tana& Yu, Lei& Zhu, Chan…[et al.]. 2018. Pirt Together with TRPV1 Is Involved in the Regulation of Neuropathic Pain. Neural Plasticity،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1210115
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Changming…[et al.]. Pirt Together with TRPV1 Is Involved in the Regulation of Neuropathic Pain. Neural Plasticity No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1210115
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Changming& Gu, Leying& Ruan, Yonglan& Gegen, Tana& Yu, Lei& Zhu, Chan…[et al.]. Pirt Together with TRPV1 Is Involved in the Regulation of Neuropathic Pain. Neural Plasticity. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1210115
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1210115
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر