Pirt Together with TRPV1 Is Involved in the Regulation of Neuropathic Pain
Joint Authors
Yu, Guang
Wang, Changming
Yang, Yan
Yu, Lei
Gu, Leying
Ruan, Yonglan
Gegen, Tana
Zhu, Chan
Zhou, Yuan
Tang, Zongxiang
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-02
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Neuropathic pain is a chronic pain and reduces the life quality of patients substantially.
Transient receptor potential vanilloid channel 1 (TRPV1), a nonselective cation channel, has been shown to play a crucial role in neuropathic pain.
Although TRPV1 plays an important role in neuropathic pain, the mechanism of how TRPV1 was regulated in neuropathic pain remains unclear.
Pirt is a membrane protein and binds to TRPV1 to enhance its activity.
It was suggested that Pirt should also be involved in neuropathic pain.
In this study, we investigated the role of Pirt in neuropathic pain (CCI model); the results show that mechanical allodynia and thermal hyperalgesia were alleviated in Pirt−/− mice in CCI models.
TRPV1 expression was increased by immunofluorescence and real-time PCR experiments.
The increase in TRPV1 expression was less in Pirt knockout mice in CCI models.
Moreover, the number of capsaicin-responding neurons and the magnitude of evoked calcium response were attenuated in DRG neurons from Pirt−/− mice in CCI models.
Finally, we found that the pain behavior attenuated in dysfunction of both Pirt and TRPV1 was much stronger than in dysfunction of Pirt or TRPV1 only in a CCI model in vitro study.
Taken together, Pirt together with TRPV1 is involved in CCI-induced neuropathic pain.
American Psychological Association (APA)
Wang, Changming& Gu, Leying& Ruan, Yonglan& Gegen, Tana& Yu, Lei& Zhu, Chan…[et al.]. 2018. Pirt Together with TRPV1 Is Involved in the Regulation of Neuropathic Pain. Neural Plasticity،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1210115
Modern Language Association (MLA)
Wang, Changming…[et al.]. Pirt Together with TRPV1 Is Involved in the Regulation of Neuropathic Pain. Neural Plasticity No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1210115
American Medical Association (AMA)
Wang, Changming& Gu, Leying& Ruan, Yonglan& Gegen, Tana& Yu, Lei& Zhu, Chan…[et al.]. Pirt Together with TRPV1 Is Involved in the Regulation of Neuropathic Pain. Neural Plasticity. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1210115
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1210115