White Matter Damage in 4,725 Term-Born Infants Is Determined by Head Circumference at Birth: The Missing Link
المؤلفون المشاركون
المصدر
Obstetrics and Gynecology International
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-02-28
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Background.
White matter damage (WMD) is a prime risk factor for cerebral palsy, in part occurring unexplained.
Though primarily a problem of preterm infants, there is growing evidence that in large newborns cephalopelvic disproportion and prolonged labor are involved.
Objective.
To explore both incidence of and morphometric risk factors for WMD in term-born infants.
Study Design.
We related growth variables and risk factors of term-born infants to WMD (61/4,725) using odds ratios of z-score bands.
Results.
The key result is the novel observation that head circumference is a prime and unique index for WMD in term-born neonates over the whole range of centiles (U-shaped; WMD (%) = 3.1168–0.12797∗HC (centile) + 0.0014741∗HC2; p<0.0001).
This suggests different mechanisms for WMD in the lowest and highest z-score band.
In the latter, cephalic pressure gradients and prolonged labor with preserved neonatal vitality prevail, whereas in the previous one, acute and chronic oxygen deprivation with reduced vitality predominate.
Conclusions.
The fact that seemingly healthy term-born neonates are not screened by head imaging, in spite of both large head circumference and prolonged labor, is considered to be the missing link between the insult that escapes diagnosis and the development of unexplained developmental delay and cerebral palsy in childhood.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jensen, A.& Holmer, Bert. 2018. White Matter Damage in 4,725 Term-Born Infants Is Determined by Head Circumference at Birth: The Missing Link. Obstetrics and Gynecology International،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1210662
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jensen, A.& Holmer, Bert. White Matter Damage in 4,725 Term-Born Infants Is Determined by Head Circumference at Birth: The Missing Link. Obstetrics and Gynecology International No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1210662
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jensen, A.& Holmer, Bert. White Matter Damage in 4,725 Term-Born Infants Is Determined by Head Circumference at Birth: The Missing Link. Obstetrics and Gynecology International. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1210662
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1210662
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر