White Matter Damage in 4,725 Term-Born Infants Is Determined by Head Circumference at Birth: The Missing Link
Joint Authors
Source
Obstetrics and Gynecology International
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-28
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Background.
White matter damage (WMD) is a prime risk factor for cerebral palsy, in part occurring unexplained.
Though primarily a problem of preterm infants, there is growing evidence that in large newborns cephalopelvic disproportion and prolonged labor are involved.
Objective.
To explore both incidence of and morphometric risk factors for WMD in term-born infants.
Study Design.
We related growth variables and risk factors of term-born infants to WMD (61/4,725) using odds ratios of z-score bands.
Results.
The key result is the novel observation that head circumference is a prime and unique index for WMD in term-born neonates over the whole range of centiles (U-shaped; WMD (%) = 3.1168–0.12797∗HC (centile) + 0.0014741∗HC2; p<0.0001).
This suggests different mechanisms for WMD in the lowest and highest z-score band.
In the latter, cephalic pressure gradients and prolonged labor with preserved neonatal vitality prevail, whereas in the previous one, acute and chronic oxygen deprivation with reduced vitality predominate.
Conclusions.
The fact that seemingly healthy term-born neonates are not screened by head imaging, in spite of both large head circumference and prolonged labor, is considered to be the missing link between the insult that escapes diagnosis and the development of unexplained developmental delay and cerebral palsy in childhood.
American Psychological Association (APA)
Jensen, A.& Holmer, Bert. 2018. White Matter Damage in 4,725 Term-Born Infants Is Determined by Head Circumference at Birth: The Missing Link. Obstetrics and Gynecology International،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1210662
Modern Language Association (MLA)
Jensen, A.& Holmer, Bert. White Matter Damage in 4,725 Term-Born Infants Is Determined by Head Circumference at Birth: The Missing Link. Obstetrics and Gynecology International No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1210662
American Medical Association (AMA)
Jensen, A.& Holmer, Bert. White Matter Damage in 4,725 Term-Born Infants Is Determined by Head Circumference at Birth: The Missing Link. Obstetrics and Gynecology International. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1210662
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1210662