Effects of Single-Nucleotide Polymorphisms in Cytokine, Toll-Like Receptor, and Progesterone Receptor Genes on Risk of Miscarriage
المؤلفون المشاركون
Razdaibiedina, Anastasiia
Khobzey, Mykhaylo
Tkachenko, Victoria
Vorobiova, Iryna
المصدر
Obstetrics and Gynecology International
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-07-17
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Spontaneous abortion is a complex, multifactorial pathology, where various genetic, neural, endocrine, and immunological factors are involved.
Cytokines, Toll-like receptors, and progesterone receptors play critical roles in embryonic implantation and development.
A delicate, stage-specific equilibrium of these proteins is required for successful pregnancy outcome.
However, genetic variation from one individual to another results in variation in levels of Th1/Th2 cytokines, strength of identification of infectious agents by Toll-like receptors, and quality of progesterone recognition.
Thus, a complex study encompassing effects of major SNPs of cytokine, TLR, and PGR genes on the risk of miscarriage is needed.
In this study, we investigated SNPs of 9 genes (TLR2 G753A, TLR4 C399T, TLR9 G2848A, TGF-β1 C509T, PGR PROGINS, IL-6 G174C, IL-8 C781T, IL-10 C592A, and TNFα G308A) in 106 women, whose pregnancy ended in miscarriage, and 74 women, who delivered in term without any pregnancy complication.
All participants are from Ukrainian population.
As a result, TLR9 and IL-10 SNPs have been found to play critical roles in the development of spontaneous abortion.
TLR2, TLR4, IL-6, IL-8, and PGR SNPs were identified as secondary factors that can also affect the risk of miscarriage.
There was no association found between TGF-β1 and TNFα polymorphisms and miscarriage.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Razdaibiedina, Anastasiia& Khobzey, Mykhaylo& Tkachenko, Victoria& Vorobiova, Iryna. 2018. Effects of Single-Nucleotide Polymorphisms in Cytokine, Toll-Like Receptor, and Progesterone Receptor Genes on Risk of Miscarriage. Obstetrics and Gynecology International،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1210711
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Razdaibiedina, Anastasiia…[et al.]. Effects of Single-Nucleotide Polymorphisms in Cytokine, Toll-Like Receptor, and Progesterone Receptor Genes on Risk of Miscarriage. Obstetrics and Gynecology International No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1210711
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Razdaibiedina, Anastasiia& Khobzey, Mykhaylo& Tkachenko, Victoria& Vorobiova, Iryna. Effects of Single-Nucleotide Polymorphisms in Cytokine, Toll-Like Receptor, and Progesterone Receptor Genes on Risk of Miscarriage. Obstetrics and Gynecology International. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1210711
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1210711
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر