Effects of Single-Nucleotide Polymorphisms in Cytokine, Toll-Like Receptor, and Progesterone Receptor Genes on Risk of Miscarriage
Joint Authors
Razdaibiedina, Anastasiia
Khobzey, Mykhaylo
Tkachenko, Victoria
Vorobiova, Iryna
Source
Obstetrics and Gynecology International
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-17
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Spontaneous abortion is a complex, multifactorial pathology, where various genetic, neural, endocrine, and immunological factors are involved.
Cytokines, Toll-like receptors, and progesterone receptors play critical roles in embryonic implantation and development.
A delicate, stage-specific equilibrium of these proteins is required for successful pregnancy outcome.
However, genetic variation from one individual to another results in variation in levels of Th1/Th2 cytokines, strength of identification of infectious agents by Toll-like receptors, and quality of progesterone recognition.
Thus, a complex study encompassing effects of major SNPs of cytokine, TLR, and PGR genes on the risk of miscarriage is needed.
In this study, we investigated SNPs of 9 genes (TLR2 G753A, TLR4 C399T, TLR9 G2848A, TGF-β1 C509T, PGR PROGINS, IL-6 G174C, IL-8 C781T, IL-10 C592A, and TNFα G308A) in 106 women, whose pregnancy ended in miscarriage, and 74 women, who delivered in term without any pregnancy complication.
All participants are from Ukrainian population.
As a result, TLR9 and IL-10 SNPs have been found to play critical roles in the development of spontaneous abortion.
TLR2, TLR4, IL-6, IL-8, and PGR SNPs were identified as secondary factors that can also affect the risk of miscarriage.
There was no association found between TGF-β1 and TNFα polymorphisms and miscarriage.
American Psychological Association (APA)
Razdaibiedina, Anastasiia& Khobzey, Mykhaylo& Tkachenko, Victoria& Vorobiova, Iryna. 2018. Effects of Single-Nucleotide Polymorphisms in Cytokine, Toll-Like Receptor, and Progesterone Receptor Genes on Risk of Miscarriage. Obstetrics and Gynecology International،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1210711
Modern Language Association (MLA)
Razdaibiedina, Anastasiia…[et al.]. Effects of Single-Nucleotide Polymorphisms in Cytokine, Toll-Like Receptor, and Progesterone Receptor Genes on Risk of Miscarriage. Obstetrics and Gynecology International No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1210711
American Medical Association (AMA)
Razdaibiedina, Anastasiia& Khobzey, Mykhaylo& Tkachenko, Victoria& Vorobiova, Iryna. Effects of Single-Nucleotide Polymorphisms in Cytokine, Toll-Like Receptor, and Progesterone Receptor Genes on Risk of Miscarriage. Obstetrics and Gynecology International. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1210711
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1210711