Beneficial Effects Exerted by Paeonol in the Management of Atherosclerosis

المؤلفون المشاركون

Lu, Li
Qin, Yating
Guo, Xiaomei
Chen, Chen

المصدر

Oxidative Medicine and Cellular Longevity

العدد

المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-11، 11ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2018-11-07

دولة النشر

مصر

عدد الصفحات

11

التخصصات الرئيسية

الأحياء

الملخص EN

Atherosclerosis, a chronic luminal stenosis disorder occurred in large and medium arteries, is the principle pathological basis of cardiovascular diseases with the highest morbidity and mortality worldwide.

In oriental countries, traditional Chinese medicine Cortex Moutan has been widely used for the treatment of atherosclerosis-related illnesses for thousands of years.

Paeonol, a bioactive monomer extracted from Cortex Moutan, is an important pharmacological component responsible for the antiatherosclerotic effects.

Numerous lines of findings have established that paeonol offers beneficial roles against the initiation and progression of atherosclerotic lesions through inhibiting proatherogenic processes, such as endothelium damage, chronic inflammation, disturbance of lipid metabolism, uncontrolled oxidative stress, excessive growth, and mobilization of vascular smooth muscle cells as well as abnormality of platelet activation.

Investigations identifying the atheroprotective effects of paeonol present substantial evidence for potential clinical application of paeonol as a therapeutic agent in atherosclerosis management.

In this review, we summarize the antiatherosclerotic actions by which paeonol suppresses atherogenesis and provide newly insights into its atheroprotective mechanisms and the future clinical practice.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Lu, Li& Qin, Yating& Chen, Chen& Guo, Xiaomei. 2018. Beneficial Effects Exerted by Paeonol in the Management of Atherosclerosis. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1210827

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Lu, Li…[et al.]. Beneficial Effects Exerted by Paeonol in the Management of Atherosclerosis. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1210827

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Lu, Li& Qin, Yating& Chen, Chen& Guo, Xiaomei. Beneficial Effects Exerted by Paeonol in the Management of Atherosclerosis. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1210827

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1210827