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Upregulation of SIRT1 by Kartogenin Enhances Antioxidant Functions and Promotes Osteogenesis in Human Mesenchymal Stem Cells
المؤلفون المشاركون
He, Fan
Chen, Xi
Yu, Jia
Ming, Pei
Lin, Jun
Pan, Guoqing
Wang, Yifan
Chen, Guangdong
Yan, Jinku
Zhu, Caihong
Zhang, Junxin
Yang, Huilin
Liu, Tao
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-07-15
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Osteoarthritis is a chronic degenerative joint disease involving both articular cartilage and subchondral bone.
Kartogenin (KGN) was recently identified to improve in vivo cartilage repair; however, its effect on bone formation is unknown.
The aim of this study was to investigate the effect of KGN on antioxidant properties and osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BM-MSCs).
Human BM-MSCs were treated with KGN at concentrations ranging from 10−8 M to 10−6 M.
Our results indicated that KGN improved cell proliferation and attenuated intracellular reactive oxygen species.
The levels of antioxidant enzymes and osteogenic differentiation of BM-MSCs were enhanced by KGN in a dose-dependent manner.
Furthermore, KGN-treated BM-MSCs showed upregulation of silent information regulator type 1 (SIRT1) and increased phosphorylation of adenosine 5′-monophosphate-activated protein kinase (AMPK), indicating that KGN activated the AMPK-SIRT1 signaling pathway in BM-MSCs.
Inhibition of SIRT1 by nicotinamide reversed the antioxidant effect of KGN on BM-MSCs and suppressed osteogenic differentiation.
In conclusion, our results demonstrated that KGN improved intracellular antioxidant properties and promoted osteogenic differentiation of BM-MSCs by activating the AMPK-SIRT1 signaling pathway.
Thus, KGN may have the potential for not only articular cartilage repair but also the clinical application of MSCs in bone tissue engineering.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Yifan& Chen, Guangdong& Yan, Jinku& Chen, Xi& He, Fan& Zhu, Caihong…[et al.]. 2018. Upregulation of SIRT1 by Kartogenin Enhances Antioxidant Functions and Promotes Osteogenesis in Human Mesenchymal Stem Cells. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1210870
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Yifan…[et al.]. Upregulation of SIRT1 by Kartogenin Enhances Antioxidant Functions and Promotes Osteogenesis in Human Mesenchymal Stem Cells. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1210870
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Yifan& Chen, Guangdong& Yan, Jinku& Chen, Xi& He, Fan& Zhu, Caihong…[et al.]. Upregulation of SIRT1 by Kartogenin Enhances Antioxidant Functions and Promotes Osteogenesis in Human Mesenchymal Stem Cells. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1210870
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1210870
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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