Carnosic Acid, a Natural Diterpene, Attenuates Arsenic-Induced Hepatotoxicity via Reducing Oxidative Stress, MAPK Activation, and Apoptotic Cell Death Pathway
المؤلفون المشاركون
Das, Sonjit
Joardar, Swarnalata
Manna, Prasenjit
Dua, Tarun K.
Bhattacharjee, Niloy
Khanra, Ritu
Bhowmick, Shovonlal
Kalita, Jatin
Saha, Achintya
Ray, Supratim
De Feo, Vincenzo
Dewanjee, Saikat
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-24، 24ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-05-02
دولة النشر
مصر
عدد الصفحات
24
التخصصات الرئيسية
الملخص EN
The present studies have been executed to explore the protective mechanism of carnosic acid (CA) against NaAsO2-induced hepatic injury.
CA exhibited a concentration dependent (1–4 μM) increase in cell viability against NaAsO2 (12 μM) in murine hepatocytes.
NaAsO2 treatment significantly enhanced the ROS-mediated oxidative stress in the hepatic cells both in in vitro and in vivo systems.
Significant activation of MAPK, NF-κB, p53, and intrinsic and extrinsic apoptotic signaling was observed in NaAsO2-exposed hepatic cells.
CA could significantly counteract with redox stress and ROS-mediated signaling and thereby attenuated NaAsO2-mediated hepatotoxicity.
NaAsO2 (10 mg/kg) treatment caused significant increment in the As bioaccumulation, cytosolic ATP level, DNA fragmentation, and oxidation in the liver of experimental mice (n=6).
The serum biochemical and haematological parameters were significantly altered in the NaAsO2-exposed mice (n=6).
Simultaneous treatment with CA (10 and 20 mg/kg) could significantly reinstate the NaAsO2-mediated toxicological effects in the liver.
Molecular docking and dynamics predicted the possible interaction patterns and the stability of interactions between CA and signal proteins.
ADME prediction anticipated the drug-likeness characteristics of CA.
Hence, there would be an option to employ CA as a new therapeutic agent against As-mediated toxic manifestations in future.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Das, Sonjit& Joardar, Swarnalata& Manna, Prasenjit& Dua, Tarun K.& Bhattacharjee, Niloy& Khanra, Ritu…[et al.]. 2018. Carnosic Acid, a Natural Diterpene, Attenuates Arsenic-Induced Hepatotoxicity via Reducing Oxidative Stress, MAPK Activation, and Apoptotic Cell Death Pathway. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-24.
https://search.emarefa.net/detail/BIM-1210874
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Das, Sonjit…[et al.]. Carnosic Acid, a Natural Diterpene, Attenuates Arsenic-Induced Hepatotoxicity via Reducing Oxidative Stress, MAPK Activation, and Apoptotic Cell Death Pathway. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-24.
https://search.emarefa.net/detail/BIM-1210874
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Das, Sonjit& Joardar, Swarnalata& Manna, Prasenjit& Dua, Tarun K.& Bhattacharjee, Niloy& Khanra, Ritu…[et al.]. Carnosic Acid, a Natural Diterpene, Attenuates Arsenic-Induced Hepatotoxicity via Reducing Oxidative Stress, MAPK Activation, and Apoptotic Cell Death Pathway. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-24.
https://search.emarefa.net/detail/BIM-1210874
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1210874
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر