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Carnosic Acid, a Natural Diterpene, Attenuates Arsenic-Induced Hepatotoxicity via Reducing Oxidative Stress, MAPK Activation, and Apoptotic Cell Death Pathway
Joint Authors
Das, Sonjit
Joardar, Swarnalata
Manna, Prasenjit
Dua, Tarun K.
Bhattacharjee, Niloy
Khanra, Ritu
Bhowmick, Shovonlal
Kalita, Jatin
Saha, Achintya
Ray, Supratim
De Feo, Vincenzo
Dewanjee, Saikat
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-24, 24 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-02
Country of Publication
Egypt
No. of Pages
24
Main Subjects
Abstract EN
The present studies have been executed to explore the protective mechanism of carnosic acid (CA) against NaAsO2-induced hepatic injury.
CA exhibited a concentration dependent (1–4 μM) increase in cell viability against NaAsO2 (12 μM) in murine hepatocytes.
NaAsO2 treatment significantly enhanced the ROS-mediated oxidative stress in the hepatic cells both in in vitro and in vivo systems.
Significant activation of MAPK, NF-κB, p53, and intrinsic and extrinsic apoptotic signaling was observed in NaAsO2-exposed hepatic cells.
CA could significantly counteract with redox stress and ROS-mediated signaling and thereby attenuated NaAsO2-mediated hepatotoxicity.
NaAsO2 (10 mg/kg) treatment caused significant increment in the As bioaccumulation, cytosolic ATP level, DNA fragmentation, and oxidation in the liver of experimental mice (n=6).
The serum biochemical and haematological parameters were significantly altered in the NaAsO2-exposed mice (n=6).
Simultaneous treatment with CA (10 and 20 mg/kg) could significantly reinstate the NaAsO2-mediated toxicological effects in the liver.
Molecular docking and dynamics predicted the possible interaction patterns and the stability of interactions between CA and signal proteins.
ADME prediction anticipated the drug-likeness characteristics of CA.
Hence, there would be an option to employ CA as a new therapeutic agent against As-mediated toxic manifestations in future.
American Psychological Association (APA)
Das, Sonjit& Joardar, Swarnalata& Manna, Prasenjit& Dua, Tarun K.& Bhattacharjee, Niloy& Khanra, Ritu…[et al.]. 2018. Carnosic Acid, a Natural Diterpene, Attenuates Arsenic-Induced Hepatotoxicity via Reducing Oxidative Stress, MAPK Activation, and Apoptotic Cell Death Pathway. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-24.
https://search.emarefa.net/detail/BIM-1210874
Modern Language Association (MLA)
Das, Sonjit…[et al.]. Carnosic Acid, a Natural Diterpene, Attenuates Arsenic-Induced Hepatotoxicity via Reducing Oxidative Stress, MAPK Activation, and Apoptotic Cell Death Pathway. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-24.
https://search.emarefa.net/detail/BIM-1210874
American Medical Association (AMA)
Das, Sonjit& Joardar, Swarnalata& Manna, Prasenjit& Dua, Tarun K.& Bhattacharjee, Niloy& Khanra, Ritu…[et al.]. Carnosic Acid, a Natural Diterpene, Attenuates Arsenic-Induced Hepatotoxicity via Reducing Oxidative Stress, MAPK Activation, and Apoptotic Cell Death Pathway. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-24.
https://search.emarefa.net/detail/BIM-1210874
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1210874