Parenteral Succinate Reduces Systemic ROS Production in Septic Rats, but It Does Not Reduce Creatinine Levels
المؤلفون المشاركون
Chapela, Sebastián
Burgos, Isabel
Congost, Christian
Canzonieri, Romina
Muryan, Alexis
Alonso, Manuel
Stella, Carlos A.
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-11-06
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
In sepsis, reactive oxygen species (ROS) production is increased.
This process takes place mainly within the electron transport chain.
ROS production is part of the pathophysiology of multiple organ failure in sepsis.
Succinate yields Dihydroflavine-Adenine Dinucleotide (FADH2), which enters the chain through complex II, avoiding complex I, through which electrons are lost.
The aim of this work is to determine if parenteral succinate reduces systemic ROS production and improves kidney function.
Rats with cecal ligation and puncture were used as model of sepsis, and 4 groups were made: Control group; Succinate group, which only received parenteral succinate; Sepsis group; and Sepsis which received parenteral succinate.
Systemic ROS are measured 24 hours after the procedure.
Rats subjected to cecal puncture treated with succinate had less systemic ROS than Septic untreated rats (p=0.007), while there were no differences in creatinine levels (p=0.07).
There was no correlation between creatinine and systemic ROS levels (p=0.3).
We concluded that parenteral succinate reduces ROS levels, but it does not reduce creatinine levels.
Since there is no correlation between both levels, the processes would not be related.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chapela, Sebastián& Burgos, Isabel& Congost, Christian& Canzonieri, Romina& Muryan, Alexis& Alonso, Manuel…[et al.]. 2018. Parenteral Succinate Reduces Systemic ROS Production in Septic Rats, but It Does Not Reduce Creatinine Levels. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1210953
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chapela, Sebastián…[et al.]. Parenteral Succinate Reduces Systemic ROS Production in Septic Rats, but It Does Not Reduce Creatinine Levels. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1210953
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chapela, Sebastián& Burgos, Isabel& Congost, Christian& Canzonieri, Romina& Muryan, Alexis& Alonso, Manuel…[et al.]. Parenteral Succinate Reduces Systemic ROS Production in Septic Rats, but It Does Not Reduce Creatinine Levels. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1210953
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1210953
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر