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Parenteral Succinate Reduces Systemic ROS Production in Septic Rats, but It Does Not Reduce Creatinine Levels
Joint Authors
Chapela, Sebastián
Burgos, Isabel
Congost, Christian
Canzonieri, Romina
Muryan, Alexis
Alonso, Manuel
Stella, Carlos A.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-06
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
In sepsis, reactive oxygen species (ROS) production is increased.
This process takes place mainly within the electron transport chain.
ROS production is part of the pathophysiology of multiple organ failure in sepsis.
Succinate yields Dihydroflavine-Adenine Dinucleotide (FADH2), which enters the chain through complex II, avoiding complex I, through which electrons are lost.
The aim of this work is to determine if parenteral succinate reduces systemic ROS production and improves kidney function.
Rats with cecal ligation and puncture were used as model of sepsis, and 4 groups were made: Control group; Succinate group, which only received parenteral succinate; Sepsis group; and Sepsis which received parenteral succinate.
Systemic ROS are measured 24 hours after the procedure.
Rats subjected to cecal puncture treated with succinate had less systemic ROS than Septic untreated rats (p=0.007), while there were no differences in creatinine levels (p=0.07).
There was no correlation between creatinine and systemic ROS levels (p=0.3).
We concluded that parenteral succinate reduces ROS levels, but it does not reduce creatinine levels.
Since there is no correlation between both levels, the processes would not be related.
American Psychological Association (APA)
Chapela, Sebastián& Burgos, Isabel& Congost, Christian& Canzonieri, Romina& Muryan, Alexis& Alonso, Manuel…[et al.]. 2018. Parenteral Succinate Reduces Systemic ROS Production in Septic Rats, but It Does Not Reduce Creatinine Levels. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1210953
Modern Language Association (MLA)
Chapela, Sebastián…[et al.]. Parenteral Succinate Reduces Systemic ROS Production in Septic Rats, but It Does Not Reduce Creatinine Levels. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1210953
American Medical Association (AMA)
Chapela, Sebastián& Burgos, Isabel& Congost, Christian& Canzonieri, Romina& Muryan, Alexis& Alonso, Manuel…[et al.]. Parenteral Succinate Reduces Systemic ROS Production in Septic Rats, but It Does Not Reduce Creatinine Levels. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1210953
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1210953