Apoptosis and Mobilization of Lymphocytes to Cardiac Tissue Is Associated with Myocardial Infarction in a Reperfused Porcine Model and Infarct Size in Post-PCI Patients
المؤلفون المشاركون
Forteza, Maria J.
Trapero, Isabel
Hervas, Arantxa
de Dios, Elena
Ruiz-Sauri, Amparo
Minana, Gema
Bonanad, Clara
Gómez, Cristina
Oltra, Ricardo
Rios-Navarro, Cesar
Ketelhuth, Daniel F. J.
Nunez, Julio
Chorro, Francisco J.
Bodi, Vicente
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-03-18
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
ST-segment elevation myocardial infarction (STEMI) is the most severe outcome of coronary artery disease.
Despite rapid reperfusion of the artery, acute irrigation of the cardiac tissue is associated with increased inflammation.
While innate immune response in STEMI is well described, an in-depth characterization of adaptive immune cell dynamics and their potential role remains elusive.
We performed a translational study using a controlled porcine reperfusion model of STEMI and the analysis of lymphocyte subsets in 116 STEMI patients undergoing percutaneous coronary intervention (PCI).
In the animal model, a sharp drop in circulating T lymphocytes occurred within the first hours after reperfusion.
Notably, increased apoptosis of circulating lymphocytes and infiltration of proinflammatory Th1 lymphocytes in the heart were observed 48 h after reperfusion.
Similarly, in STEMI patients, a sharp drop in circulating T lymphocyte subsets occurred within the first 24 h post-PCI.
A cardiac magnetic resonance (CMR) evaluation of these patients revealed an inverse association between 24 h circulating T lymphocyte numbers and infarction size at 1-week and 6-month post-PCI.
Our translational approach revealed striking changes in the circulating and tissue-infiltrating T lymphocyte repertoire in response to ischemia-reperfusion.
These findings may help in developing new diagnostic and therapeutic approaches for coronary diseases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Forteza, Maria J.& Trapero, Isabel& Hervas, Arantxa& de Dios, Elena& Ruiz-Sauri, Amparo& Minana, Gema…[et al.]. 2018. Apoptosis and Mobilization of Lymphocytes to Cardiac Tissue Is Associated with Myocardial Infarction in a Reperfused Porcine Model and Infarct Size in Post-PCI Patients. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1210959
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Forteza, Maria J.…[et al.]. Apoptosis and Mobilization of Lymphocytes to Cardiac Tissue Is Associated with Myocardial Infarction in a Reperfused Porcine Model and Infarct Size in Post-PCI Patients. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1210959
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Forteza, Maria J.& Trapero, Isabel& Hervas, Arantxa& de Dios, Elena& Ruiz-Sauri, Amparo& Minana, Gema…[et al.]. Apoptosis and Mobilization of Lymphocytes to Cardiac Tissue Is Associated with Myocardial Infarction in a Reperfused Porcine Model and Infarct Size in Post-PCI Patients. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1210959
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1210959
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر