Apoptosis and Mobilization of Lymphocytes to Cardiac Tissue Is Associated with Myocardial Infarction in a Reperfused Porcine Model and Infarct Size in Post-PCI Patients
Joint Authors
Forteza, Maria J.
Trapero, Isabel
Hervas, Arantxa
de Dios, Elena
Ruiz-Sauri, Amparo
Minana, Gema
Bonanad, Clara
Gómez, Cristina
Oltra, Ricardo
Rios-Navarro, Cesar
Ketelhuth, Daniel F. J.
Nunez, Julio
Chorro, Francisco J.
Bodi, Vicente
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
ST-segment elevation myocardial infarction (STEMI) is the most severe outcome of coronary artery disease.
Despite rapid reperfusion of the artery, acute irrigation of the cardiac tissue is associated with increased inflammation.
While innate immune response in STEMI is well described, an in-depth characterization of adaptive immune cell dynamics and their potential role remains elusive.
We performed a translational study using a controlled porcine reperfusion model of STEMI and the analysis of lymphocyte subsets in 116 STEMI patients undergoing percutaneous coronary intervention (PCI).
In the animal model, a sharp drop in circulating T lymphocytes occurred within the first hours after reperfusion.
Notably, increased apoptosis of circulating lymphocytes and infiltration of proinflammatory Th1 lymphocytes in the heart were observed 48 h after reperfusion.
Similarly, in STEMI patients, a sharp drop in circulating T lymphocyte subsets occurred within the first 24 h post-PCI.
A cardiac magnetic resonance (CMR) evaluation of these patients revealed an inverse association between 24 h circulating T lymphocyte numbers and infarction size at 1-week and 6-month post-PCI.
Our translational approach revealed striking changes in the circulating and tissue-infiltrating T lymphocyte repertoire in response to ischemia-reperfusion.
These findings may help in developing new diagnostic and therapeutic approaches for coronary diseases.
American Psychological Association (APA)
Forteza, Maria J.& Trapero, Isabel& Hervas, Arantxa& de Dios, Elena& Ruiz-Sauri, Amparo& Minana, Gema…[et al.]. 2018. Apoptosis and Mobilization of Lymphocytes to Cardiac Tissue Is Associated with Myocardial Infarction in a Reperfused Porcine Model and Infarct Size in Post-PCI Patients. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1210959
Modern Language Association (MLA)
Forteza, Maria J.…[et al.]. Apoptosis and Mobilization of Lymphocytes to Cardiac Tissue Is Associated with Myocardial Infarction in a Reperfused Porcine Model and Infarct Size in Post-PCI Patients. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1210959
American Medical Association (AMA)
Forteza, Maria J.& Trapero, Isabel& Hervas, Arantxa& de Dios, Elena& Ruiz-Sauri, Amparo& Minana, Gema…[et al.]. Apoptosis and Mobilization of Lymphocytes to Cardiac Tissue Is Associated with Myocardial Infarction in a Reperfused Porcine Model and Infarct Size in Post-PCI Patients. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1210959
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1210959