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Anti-Inflammatory and Antioxidant Actions of Methyl Jasmonate Are Associated with Metabolic Modifications in the Liver of Arthritic Rats
المؤلفون المشاركون
Bracht, Adelar
Sá-Nakanishi, Anacharis Babeto de
Silva-Comar, Francielli Maria de Souza
Peralta, Rosane M.
Moreira, Lucas S.
Gonçalves, Geferson A.
Bracht, Lívia
Comar, Jurandir F.
Neto, Jamil Soni
Bersani-Amado, Ciomar Aparecida
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-08-23
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Methyl jasmonate (MeJA) is a fatty acid-derived cyclopentanone which shares structural similarities with prostaglandins and has been under study as a promising anti-inflammatory agent.
This study investigated the actions of MeJA on systemic inflammation and oxidative status in rats with adjuvant-induced arthritis, a model for rheumatoid arthritis.
MeJA (75 to 300 mg·kg−1) was administrated orally during 18 days after arthritis induction with Freund’s adjuvant.
Articular and systemic inflammation was greatly increased in arthritic rats, likewise the oxidative stress in plasma and liver.
The hepatic glucokinase activity and glycolysis were increased in arthritic rats.
MeJA decreased most inflammatory parameters and abolished the increased protein carbonylation in plasma and liver, diminished the increased hepatic ROS content, and restored the hepatic GSH/GSSG ratio in arthritic rats.
However, the MeJA treatment decreased the hepatic glucokinase activity and glycolysis and stimulated mitochondrial ROS production in healthy and arthritic rats.
Oxygen uptake was increased by MeJA only in livers from treated arthritic rats.
This action may bear relation to the increased activity of mitochondrial NADP+-dependent enzymes to provide reducing equivalents for the glutathione cycle.
These beneficial effects, however, are associated with a decreased glucose flux through the glycolysis in the liver of arthritic and healthy rats.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sá-Nakanishi, Anacharis Babeto de& Neto, Jamil Soni& Moreira, Lucas S.& Gonçalves, Geferson A.& Silva-Comar, Francielli Maria de Souza& Bracht, Lívia…[et al.]. 2018. Anti-Inflammatory and Antioxidant Actions of Methyl Jasmonate Are Associated with Metabolic Modifications in the Liver of Arthritic Rats. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1210977
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sá-Nakanishi, Anacharis Babeto de…[et al.]. Anti-Inflammatory and Antioxidant Actions of Methyl Jasmonate Are Associated with Metabolic Modifications in the Liver of Arthritic Rats. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-16.
https://search.emarefa.net/detail/BIM-1210977
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sá-Nakanishi, Anacharis Babeto de& Neto, Jamil Soni& Moreira, Lucas S.& Gonçalves, Geferson A.& Silva-Comar, Francielli Maria de Souza& Bracht, Lívia…[et al.]. Anti-Inflammatory and Antioxidant Actions of Methyl Jasmonate Are Associated with Metabolic Modifications in the Liver of Arthritic Rats. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1210977
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1210977
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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