Anti-Inflammatory and Antioxidant Actions of Methyl Jasmonate Are Associated with Metabolic Modifications in the Liver of Arthritic Rats
Joint Authors
Bracht, Adelar
Sá-Nakanishi, Anacharis Babeto de
Silva-Comar, Francielli Maria de Souza
Peralta, Rosane M.
Moreira, Lucas S.
Gonçalves, Geferson A.
Bracht, Lívia
Comar, Jurandir F.
Neto, Jamil Soni
Bersani-Amado, Ciomar Aparecida
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-23
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Methyl jasmonate (MeJA) is a fatty acid-derived cyclopentanone which shares structural similarities with prostaglandins and has been under study as a promising anti-inflammatory agent.
This study investigated the actions of MeJA on systemic inflammation and oxidative status in rats with adjuvant-induced arthritis, a model for rheumatoid arthritis.
MeJA (75 to 300 mg·kg−1) was administrated orally during 18 days after arthritis induction with Freund’s adjuvant.
Articular and systemic inflammation was greatly increased in arthritic rats, likewise the oxidative stress in plasma and liver.
The hepatic glucokinase activity and glycolysis were increased in arthritic rats.
MeJA decreased most inflammatory parameters and abolished the increased protein carbonylation in plasma and liver, diminished the increased hepatic ROS content, and restored the hepatic GSH/GSSG ratio in arthritic rats.
However, the MeJA treatment decreased the hepatic glucokinase activity and glycolysis and stimulated mitochondrial ROS production in healthy and arthritic rats.
Oxygen uptake was increased by MeJA only in livers from treated arthritic rats.
This action may bear relation to the increased activity of mitochondrial NADP+-dependent enzymes to provide reducing equivalents for the glutathione cycle.
These beneficial effects, however, are associated with a decreased glucose flux through the glycolysis in the liver of arthritic and healthy rats.
American Psychological Association (APA)
Sá-Nakanishi, Anacharis Babeto de& Neto, Jamil Soni& Moreira, Lucas S.& Gonçalves, Geferson A.& Silva-Comar, Francielli Maria de Souza& Bracht, Lívia…[et al.]. 2018. Anti-Inflammatory and Antioxidant Actions of Methyl Jasmonate Are Associated with Metabolic Modifications in the Liver of Arthritic Rats. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1210977
Modern Language Association (MLA)
Sá-Nakanishi, Anacharis Babeto de…[et al.]. Anti-Inflammatory and Antioxidant Actions of Methyl Jasmonate Are Associated with Metabolic Modifications in the Liver of Arthritic Rats. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-16.
https://search.emarefa.net/detail/BIM-1210977
American Medical Association (AMA)
Sá-Nakanishi, Anacharis Babeto de& Neto, Jamil Soni& Moreira, Lucas S.& Gonçalves, Geferson A.& Silva-Comar, Francielli Maria de Souza& Bracht, Lívia…[et al.]. Anti-Inflammatory and Antioxidant Actions of Methyl Jasmonate Are Associated with Metabolic Modifications in the Liver of Arthritic Rats. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1210977
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1210977