![](/images/graphics-bg.png)
Anacardium microcarpum Promotes Neuroprotection Dependently of AKT and ERK Phosphorylation but Does Not Prevent Mitochondrial Damage by 6-OHDA
المؤلفون المشاركون
Echeverria Macedo, Giulianna
Kemmerich Martins, Illana
Franco, Jeferson Luis
Posser, Thaís
Rodrigues, Nathane Rosa
Ziech, Cynthia Camila
de Carvalho, Nelson Rodrigues
Vinadé, Lúcia
Filho, Valter Menezes Barbosa
de Menezes, Irwin Rose Alencar
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-10-29
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Parkinson’s disease is a degenerative and progressive illness characterized by the degeneration of dopaminergic neurons.
6-hydroxydopamine (6-OHDA) is a widespread model for induction of molecular and behavioral alterations similar to Parkinson and has contributed for testing of compounds with neuroprotective potential.
The Brazilian plant Anacardium microcarpum is used in folk medicine for treatment of several illnesses; however, the knowledge about toxicology and biological effects for this plant is very rare.
The neuroprotective effect from hydroalcoholic extract and methanolic and acetate fraction of A.
microcarpum on 6-OHDA-induced damage on chicken brain slices was investigated in this study.
6-OHDA decreased cellular viability measured by MTT reduction assay, induced lipid peroxidation by HPLC, stimulated Glutathione-S-Transferase and Thioredoxin Reductase activity, and decreased Glutathione Peroxidase activity and the total content of thiols containing compounds.
The methanolic fraction of A.
microcarpum presented the better neuroprotective effects in 6-OHDA-induced damage in relation with hydroalcoholic and acetate fraction.
The presence of AKT and ERK1/2 pharmacological inhibitors blocked the protective effect of methanolic fraction suggesting the involvement of survival pathways in the neuroprotection by the plant.
The plant did not prevent 6-OHDA autoxidation or 6-OHDA-induced mitochondrial dysfunction.
Thus, the neuroprotective effect of the methanolic fraction of A.
microcarpum appears to be attributed in part to chelating properties of extract toward reactive species and is dependent on ERK1/2 and AKT phosphorylation.
This study contributes to the understanding of biochemical mechanisms implied in neuroprotective effects of the vegetal species A.
microcarpum.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kemmerich Martins, Illana& de Carvalho, Nelson Rodrigues& Echeverria Macedo, Giulianna& Rodrigues, Nathane Rosa& Ziech, Cynthia Camila& Vinadé, Lúcia…[et al.]. 2018. Anacardium microcarpum Promotes Neuroprotection Dependently of AKT and ERK Phosphorylation but Does Not Prevent Mitochondrial Damage by 6-OHDA. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1210991
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kemmerich Martins, Illana…[et al.]. Anacardium microcarpum Promotes Neuroprotection Dependently of AKT and ERK Phosphorylation but Does Not Prevent Mitochondrial Damage by 6-OHDA. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1210991
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kemmerich Martins, Illana& de Carvalho, Nelson Rodrigues& Echeverria Macedo, Giulianna& Rodrigues, Nathane Rosa& Ziech, Cynthia Camila& Vinadé, Lúcia…[et al.]. Anacardium microcarpum Promotes Neuroprotection Dependently of AKT and ERK Phosphorylation but Does Not Prevent Mitochondrial Damage by 6-OHDA. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1210991
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1210991
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)