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Anacardium microcarpum Promotes Neuroprotection Dependently of AKT and ERK Phosphorylation but Does Not Prevent Mitochondrial Damage by 6-OHDA
Joint Authors
Echeverria Macedo, Giulianna
Kemmerich Martins, Illana
Franco, Jeferson Luis
Posser, Thaís
Rodrigues, Nathane Rosa
Ziech, Cynthia Camila
de Carvalho, Nelson Rodrigues
Vinadé, Lúcia
Filho, Valter Menezes Barbosa
de Menezes, Irwin Rose Alencar
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-29
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Parkinson’s disease is a degenerative and progressive illness characterized by the degeneration of dopaminergic neurons.
6-hydroxydopamine (6-OHDA) is a widespread model for induction of molecular and behavioral alterations similar to Parkinson and has contributed for testing of compounds with neuroprotective potential.
The Brazilian plant Anacardium microcarpum is used in folk medicine for treatment of several illnesses; however, the knowledge about toxicology and biological effects for this plant is very rare.
The neuroprotective effect from hydroalcoholic extract and methanolic and acetate fraction of A.
microcarpum on 6-OHDA-induced damage on chicken brain slices was investigated in this study.
6-OHDA decreased cellular viability measured by MTT reduction assay, induced lipid peroxidation by HPLC, stimulated Glutathione-S-Transferase and Thioredoxin Reductase activity, and decreased Glutathione Peroxidase activity and the total content of thiols containing compounds.
The methanolic fraction of A.
microcarpum presented the better neuroprotective effects in 6-OHDA-induced damage in relation with hydroalcoholic and acetate fraction.
The presence of AKT and ERK1/2 pharmacological inhibitors blocked the protective effect of methanolic fraction suggesting the involvement of survival pathways in the neuroprotection by the plant.
The plant did not prevent 6-OHDA autoxidation or 6-OHDA-induced mitochondrial dysfunction.
Thus, the neuroprotective effect of the methanolic fraction of A.
microcarpum appears to be attributed in part to chelating properties of extract toward reactive species and is dependent on ERK1/2 and AKT phosphorylation.
This study contributes to the understanding of biochemical mechanisms implied in neuroprotective effects of the vegetal species A.
microcarpum.
American Psychological Association (APA)
Kemmerich Martins, Illana& de Carvalho, Nelson Rodrigues& Echeverria Macedo, Giulianna& Rodrigues, Nathane Rosa& Ziech, Cynthia Camila& Vinadé, Lúcia…[et al.]. 2018. Anacardium microcarpum Promotes Neuroprotection Dependently of AKT and ERK Phosphorylation but Does Not Prevent Mitochondrial Damage by 6-OHDA. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1210991
Modern Language Association (MLA)
Kemmerich Martins, Illana…[et al.]. Anacardium microcarpum Promotes Neuroprotection Dependently of AKT and ERK Phosphorylation but Does Not Prevent Mitochondrial Damage by 6-OHDA. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1210991
American Medical Association (AMA)
Kemmerich Martins, Illana& de Carvalho, Nelson Rodrigues& Echeverria Macedo, Giulianna& Rodrigues, Nathane Rosa& Ziech, Cynthia Camila& Vinadé, Lúcia…[et al.]. Anacardium microcarpum Promotes Neuroprotection Dependently of AKT and ERK Phosphorylation but Does Not Prevent Mitochondrial Damage by 6-OHDA. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1210991
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1210991