Long-Term Exercise Protects against Cellular Stresses in Aged Mice
المؤلفون المشاركون
Atalay, M.
Kumagai, Shuzo
Giniatullin, R. A.
Belaya, Irina
Suwa, Masataka
Chen, Tao
Kanninen, Katja
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-03-25
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
The current study examined the effect of aging and long-term wheel-running on the expression of heat shock protein (HSP), redox regulation, and endoplasmic reticulum (ER) stress markers in tibialis anterior (T.A.) and soleus muscle of mice.
Male mice were divided into young (Y, 3-month-old), old-sedentary (OS, 24-month-old), and old-exercise (OE, 24-month-old) groups.
The OE group started voluntary wheel-running at 3 months and continued until 24 months of age.
Aging was associated with a higher thioredoxin-interacting protein (TxNiP) level, lower thioredoxin-1 (TRX-1) to TxNiP ratio—a determinant of redox regulation and increased CHOP, an indicator of ER stress-related apoptosis signaling in both muscles.
Notably, GRP78, a key indicator of ER stress, was selectively elevated in T.A.
Long-term exercise decreased TxNiP in T.A.
and soleus muscles and increased the TRX-1/TxNiP ratio in soleus muscle of aged mice.
Inducible HSP70 and constituent HSC70 were upregulated, whereas CHOP was reduced after exercise in soleus muscle.
Thus, our data demonstrated that aging induced oxidative stress and activated ER stress-related apoptosis signaling in skeletal muscle, whereas long-term wheel-running improved redox regulation, ER stress adaptation and attenuated ER stress-related apoptosis signaling.
These findings suggest that life-long exercise can protect against age-related cellular stress.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Belaya, Irina& Suwa, Masataka& Chen, Tao& Giniatullin, R. A.& Kanninen, Katja& Atalay, M.…[et al.]. 2018. Long-Term Exercise Protects against Cellular Stresses in Aged Mice. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1211123
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Belaya, Irina…[et al.]. Long-Term Exercise Protects against Cellular Stresses in Aged Mice. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1211123
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Belaya, Irina& Suwa, Masataka& Chen, Tao& Giniatullin, R. A.& Kanninen, Katja& Atalay, M.…[et al.]. Long-Term Exercise Protects against Cellular Stresses in Aged Mice. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1211123
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1211123
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر