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Long-Term Exercise Protects against Cellular Stresses in Aged Mice
Joint Authors
Atalay, M.
Kumagai, Shuzo
Giniatullin, R. A.
Belaya, Irina
Suwa, Masataka
Chen, Tao
Kanninen, Katja
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-25
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The current study examined the effect of aging and long-term wheel-running on the expression of heat shock protein (HSP), redox regulation, and endoplasmic reticulum (ER) stress markers in tibialis anterior (T.A.) and soleus muscle of mice.
Male mice were divided into young (Y, 3-month-old), old-sedentary (OS, 24-month-old), and old-exercise (OE, 24-month-old) groups.
The OE group started voluntary wheel-running at 3 months and continued until 24 months of age.
Aging was associated with a higher thioredoxin-interacting protein (TxNiP) level, lower thioredoxin-1 (TRX-1) to TxNiP ratio—a determinant of redox regulation and increased CHOP, an indicator of ER stress-related apoptosis signaling in both muscles.
Notably, GRP78, a key indicator of ER stress, was selectively elevated in T.A.
Long-term exercise decreased TxNiP in T.A.
and soleus muscles and increased the TRX-1/TxNiP ratio in soleus muscle of aged mice.
Inducible HSP70 and constituent HSC70 were upregulated, whereas CHOP was reduced after exercise in soleus muscle.
Thus, our data demonstrated that aging induced oxidative stress and activated ER stress-related apoptosis signaling in skeletal muscle, whereas long-term wheel-running improved redox regulation, ER stress adaptation and attenuated ER stress-related apoptosis signaling.
These findings suggest that life-long exercise can protect against age-related cellular stress.
American Psychological Association (APA)
Belaya, Irina& Suwa, Masataka& Chen, Tao& Giniatullin, R. A.& Kanninen, Katja& Atalay, M.…[et al.]. 2018. Long-Term Exercise Protects against Cellular Stresses in Aged Mice. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1211123
Modern Language Association (MLA)
Belaya, Irina…[et al.]. Long-Term Exercise Protects against Cellular Stresses in Aged Mice. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1211123
American Medical Association (AMA)
Belaya, Irina& Suwa, Masataka& Chen, Tao& Giniatullin, R. A.& Kanninen, Katja& Atalay, M.…[et al.]. Long-Term Exercise Protects against Cellular Stresses in Aged Mice. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1211123
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211123