Protective Effects of Different Kinds of Filtered Water on Hypertensive Mouse by Suppressing Oxidative Stress and Inflammation
المؤلفون المشاركون
Sun, Qian
Xin, Fan
Wen, Xinan
Lu, Chan
Chen, Ronghe
Ruan, Guohong
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-12-02
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Oxidative stress and inflammation play an important role in hypertensive animals and patients.
Hydrogen plays a role of antioxidation and anti-inflammation.
Calcium and magnesium play an important role in reducing hypertension and antioxidant.
Filtered water contains abundant hydrogen and a large number of other essential elements of the human body.
We investigated the protective effects of filtered water on hypertensive mice.
To establish hypertension model, ICR mice were administered with N′-nitro-L-arginine methyl ester (L-NAME) hydrochloride 64 mg/kg per day for 1 month.
The hypertensive mice were, respectively, administered with pure water, tap water, and filtered water for 2 months.
Lipid peroxidation, antioxidant enzymatic activity, endothelin-1 (ET-1), angiotensin II (Ang II), and proinflammatory cytokines (TNF-α, IL-6, and IL-1β) were assessed.
Expressions of phosphorylated NF-κB P65 in the kidney were analyzed by western blot.
qRT-PCR analysis was adopted to determine the expression levels of the proinflammatory cytokines and NF-κB P65.
The results demonstrated that filtered water can reduce the blood pressure.
Filtered water treatment restored the activity of antioxidant enzymes, downregulated ET-1, and Ang II in the serum of mice.
Filtered water treatment suppressed proinflammatory cytokines and decreased the mRNA expression of TNF-α, IL-6, IL-1β, and NF-κB P65.
Consumption of filtered water inhibited the expression of NF-κB P65.
This suggests that filtered water can reduce the blood pressure.
The protection mechanisms include downregulating oxidative stress and inhibiting inflammation, which is partly due to the inhibition of the NF-κB signaling pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sun, Qian& Xin, Fan& Wen, Xinan& Lu, Chan& Chen, Ronghe& Ruan, Guohong. 2018. Protective Effects of Different Kinds of Filtered Water on Hypertensive Mouse by Suppressing Oxidative Stress and Inflammation. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1211127
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sun, Qian…[et al.]. Protective Effects of Different Kinds of Filtered Water on Hypertensive Mouse by Suppressing Oxidative Stress and Inflammation. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1211127
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sun, Qian& Xin, Fan& Wen, Xinan& Lu, Chan& Chen, Ronghe& Ruan, Guohong. Protective Effects of Different Kinds of Filtered Water on Hypertensive Mouse by Suppressing Oxidative Stress and Inflammation. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1211127
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1211127
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر