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Protective Effects of Different Kinds of Filtered Water on Hypertensive Mouse by Suppressing Oxidative Stress and Inflammation
Joint Authors
Sun, Qian
Xin, Fan
Wen, Xinan
Lu, Chan
Chen, Ronghe
Ruan, Guohong
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Oxidative stress and inflammation play an important role in hypertensive animals and patients.
Hydrogen plays a role of antioxidation and anti-inflammation.
Calcium and magnesium play an important role in reducing hypertension and antioxidant.
Filtered water contains abundant hydrogen and a large number of other essential elements of the human body.
We investigated the protective effects of filtered water on hypertensive mice.
To establish hypertension model, ICR mice were administered with N′-nitro-L-arginine methyl ester (L-NAME) hydrochloride 64 mg/kg per day for 1 month.
The hypertensive mice were, respectively, administered with pure water, tap water, and filtered water for 2 months.
Lipid peroxidation, antioxidant enzymatic activity, endothelin-1 (ET-1), angiotensin II (Ang II), and proinflammatory cytokines (TNF-α, IL-6, and IL-1β) were assessed.
Expressions of phosphorylated NF-κB P65 in the kidney were analyzed by western blot.
qRT-PCR analysis was adopted to determine the expression levels of the proinflammatory cytokines and NF-κB P65.
The results demonstrated that filtered water can reduce the blood pressure.
Filtered water treatment restored the activity of antioxidant enzymes, downregulated ET-1, and Ang II in the serum of mice.
Filtered water treatment suppressed proinflammatory cytokines and decreased the mRNA expression of TNF-α, IL-6, IL-1β, and NF-κB P65.
Consumption of filtered water inhibited the expression of NF-κB P65.
This suggests that filtered water can reduce the blood pressure.
The protection mechanisms include downregulating oxidative stress and inhibiting inflammation, which is partly due to the inhibition of the NF-κB signaling pathway.
American Psychological Association (APA)
Sun, Qian& Xin, Fan& Wen, Xinan& Lu, Chan& Chen, Ronghe& Ruan, Guohong. 2018. Protective Effects of Different Kinds of Filtered Water on Hypertensive Mouse by Suppressing Oxidative Stress and Inflammation. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1211127
Modern Language Association (MLA)
Sun, Qian…[et al.]. Protective Effects of Different Kinds of Filtered Water on Hypertensive Mouse by Suppressing Oxidative Stress and Inflammation. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1211127
American Medical Association (AMA)
Sun, Qian& Xin, Fan& Wen, Xinan& Lu, Chan& Chen, Ronghe& Ruan, Guohong. Protective Effects of Different Kinds of Filtered Water on Hypertensive Mouse by Suppressing Oxidative Stress and Inflammation. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1211127
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211127