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Yeast Cells Exposed to Exogenous Palmitoleic Acid Either Adapt to Stress and Survive or Commit to Regulated Liponecrosis and Die
المؤلفون المشاركون
Medkour, Younes
Dakik, Paméla
Mohammad, Karamat
Mitrofanova, Darya
Titorenko, Vladimir I.
McAuley, Mélissa
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-01-31
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
A disturbed homeostasis of cellular lipids and the resulting lipotoxicity are considered to be key contributors to many human pathologies, including obesity, metabolic syndrome, type 2 diabetes, cardiovascular diseases, and cancer.
The yeast Saccharomyces cerevisiae has been successfully used for uncovering molecular mechanisms through which impaired lipid metabolism causes lipotoxicity and elicits different forms of regulated cell death.
Here, we discuss mechanisms of the “liponecrotic” mode of regulated cell death in S.
cerevisiae.
This mode of regulated cell death can be initiated in response to a brief treatment of yeast with exogenous palmitoleic acid.
Such treatment prompts the incorporation of exogenously added palmitoleic acid into phospholipids and neutral lipids.
This orchestrates a global remodeling of lipid metabolism and transfer in the endoplasmic reticulum, mitochondria, lipid droplets, and the plasma membrane.
Certain features of such remodeling play essential roles either in committing yeast to liponecrosis or in executing this mode of regulated cell death.
We also outline four processes through which yeast cells actively resist liponecrosis by adapting to the cellular stress imposed by palmitoleic acid and maintaining viability.
These prosurvival cellular processes are confined in the endoplasmic reticulum, lipid droplets, peroxisomes, autophagosomes, vacuoles, and the cytosol.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mohammad, Karamat& Dakik, Paméla& Medkour, Younes& McAuley, Mélissa& Mitrofanova, Darya& Titorenko, Vladimir I.. 2018. Yeast Cells Exposed to Exogenous Palmitoleic Acid Either Adapt to Stress and Survive or Commit to Regulated Liponecrosis and Die. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1211143
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mohammad, Karamat…[et al.]. Yeast Cells Exposed to Exogenous Palmitoleic Acid Either Adapt to Stress and Survive or Commit to Regulated Liponecrosis and Die. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1211143
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mohammad, Karamat& Dakik, Paméla& Medkour, Younes& McAuley, Mélissa& Mitrofanova, Darya& Titorenko, Vladimir I.. Yeast Cells Exposed to Exogenous Palmitoleic Acid Either Adapt to Stress and Survive or Commit to Regulated Liponecrosis and Die. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1211143
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1211143
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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