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Yeast Cells Exposed to Exogenous Palmitoleic Acid Either Adapt to Stress and Survive or Commit to Regulated Liponecrosis and Die
Joint Authors
Medkour, Younes
Dakik, Paméla
Mohammad, Karamat
Mitrofanova, Darya
Titorenko, Vladimir I.
McAuley, Mélissa
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-31
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
A disturbed homeostasis of cellular lipids and the resulting lipotoxicity are considered to be key contributors to many human pathologies, including obesity, metabolic syndrome, type 2 diabetes, cardiovascular diseases, and cancer.
The yeast Saccharomyces cerevisiae has been successfully used for uncovering molecular mechanisms through which impaired lipid metabolism causes lipotoxicity and elicits different forms of regulated cell death.
Here, we discuss mechanisms of the “liponecrotic” mode of regulated cell death in S.
cerevisiae.
This mode of regulated cell death can be initiated in response to a brief treatment of yeast with exogenous palmitoleic acid.
Such treatment prompts the incorporation of exogenously added palmitoleic acid into phospholipids and neutral lipids.
This orchestrates a global remodeling of lipid metabolism and transfer in the endoplasmic reticulum, mitochondria, lipid droplets, and the plasma membrane.
Certain features of such remodeling play essential roles either in committing yeast to liponecrosis or in executing this mode of regulated cell death.
We also outline four processes through which yeast cells actively resist liponecrosis by adapting to the cellular stress imposed by palmitoleic acid and maintaining viability.
These prosurvival cellular processes are confined in the endoplasmic reticulum, lipid droplets, peroxisomes, autophagosomes, vacuoles, and the cytosol.
American Psychological Association (APA)
Mohammad, Karamat& Dakik, Paméla& Medkour, Younes& McAuley, Mélissa& Mitrofanova, Darya& Titorenko, Vladimir I.. 2018. Yeast Cells Exposed to Exogenous Palmitoleic Acid Either Adapt to Stress and Survive or Commit to Regulated Liponecrosis and Die. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1211143
Modern Language Association (MLA)
Mohammad, Karamat…[et al.]. Yeast Cells Exposed to Exogenous Palmitoleic Acid Either Adapt to Stress and Survive or Commit to Regulated Liponecrosis and Die. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1211143
American Medical Association (AMA)
Mohammad, Karamat& Dakik, Paméla& Medkour, Younes& McAuley, Mélissa& Mitrofanova, Darya& Titorenko, Vladimir I.. Yeast Cells Exposed to Exogenous Palmitoleic Acid Either Adapt to Stress and Survive or Commit to Regulated Liponecrosis and Die. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1211143
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211143