Curcumin Inhibits Acute Vascular Inflammation through the Activation of Heme Oxygenase-1
المؤلفون المشاركون
Cheng, Jinquan
Xiao, Yunjun
Xia, Junjie
Wu, Shuang
Lv, Ziquan
Huang, Suli
Huang, Haiyan
Su, Xuefen
Ke, Yuebin
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-09-20
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Curcumin has several therapeutic properties such as anti-inflammatory effect.
Heme oxygenase-1 (HO-1) has been showed to have cytoprotective effects in some pathological conditions.
However, the role of HO-1 in anti-inflammatory effect of curcumin is unknown.
In this study, we investigate whether the anti-inflammatory effect of curcumin in vascular may be involved in the activation of HO-1.
New Zealand white rabbits were fed regular control diet or control diet added with 0.3% curcumin (wt/wt) for four weeks.
Acute vascular inflammation of rabbits was induced by putting a collar on the left common carotid artery for 24 hours.
HO-1 inhibitor and siRNA were used to investigate the role of HO-1 in the anti-inflammatory effect of curcumin in collared vascular.
We also explored the mechanism of curcumin-induced activation of HO-1 in vitro.
The serum bilirubin and vascular, liver, and spleen HO-1 mRNA levels were significantly increased in curcumin-treated rabbits.
The vascular inflammation was significantly decreased in the curcumin-treated animals compared with the control.
Treatment of the rabbits with an inhibitor of HO or HO-1 siRNA to knock down the carotid artery HO-1 abolished the ability of curcumin to inhibit vascular inflammation.
Treatment of cultured human artery endothelial cells with curcumin induced the HO-1 expression through the activation of nuclear factor-E2-related factor 2 (Nrf2) and an antioxidant responsive element via the p38 MAPK signalling pathway.
In conclusion, curcumin inhibits vascular inflammation in vivo and in vitro through the activation of HO-1.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xiao, Yunjun& Xia, Junjie& Wu, Shuang& Lv, Ziquan& Huang, Suli& Huang, Haiyan…[et al.]. 2018. Curcumin Inhibits Acute Vascular Inflammation through the Activation of Heme Oxygenase-1. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1211223
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xiao, Yunjun…[et al.]. Curcumin Inhibits Acute Vascular Inflammation through the Activation of Heme Oxygenase-1. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1211223
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xiao, Yunjun& Xia, Junjie& Wu, Shuang& Lv, Ziquan& Huang, Suli& Huang, Haiyan…[et al.]. Curcumin Inhibits Acute Vascular Inflammation through the Activation of Heme Oxygenase-1. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1211223
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1211223
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر