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Curcumin Inhibits Acute Vascular Inflammation through the Activation of Heme Oxygenase-1
Joint Authors
Cheng, Jinquan
Xiao, Yunjun
Xia, Junjie
Wu, Shuang
Lv, Ziquan
Huang, Suli
Huang, Haiyan
Su, Xuefen
Ke, Yuebin
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-20
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Curcumin has several therapeutic properties such as anti-inflammatory effect.
Heme oxygenase-1 (HO-1) has been showed to have cytoprotective effects in some pathological conditions.
However, the role of HO-1 in anti-inflammatory effect of curcumin is unknown.
In this study, we investigate whether the anti-inflammatory effect of curcumin in vascular may be involved in the activation of HO-1.
New Zealand white rabbits were fed regular control diet or control diet added with 0.3% curcumin (wt/wt) for four weeks.
Acute vascular inflammation of rabbits was induced by putting a collar on the left common carotid artery for 24 hours.
HO-1 inhibitor and siRNA were used to investigate the role of HO-1 in the anti-inflammatory effect of curcumin in collared vascular.
We also explored the mechanism of curcumin-induced activation of HO-1 in vitro.
The serum bilirubin and vascular, liver, and spleen HO-1 mRNA levels were significantly increased in curcumin-treated rabbits.
The vascular inflammation was significantly decreased in the curcumin-treated animals compared with the control.
Treatment of the rabbits with an inhibitor of HO or HO-1 siRNA to knock down the carotid artery HO-1 abolished the ability of curcumin to inhibit vascular inflammation.
Treatment of cultured human artery endothelial cells with curcumin induced the HO-1 expression through the activation of nuclear factor-E2-related factor 2 (Nrf2) and an antioxidant responsive element via the p38 MAPK signalling pathway.
In conclusion, curcumin inhibits vascular inflammation in vivo and in vitro through the activation of HO-1.
American Psychological Association (APA)
Xiao, Yunjun& Xia, Junjie& Wu, Shuang& Lv, Ziquan& Huang, Suli& Huang, Haiyan…[et al.]. 2018. Curcumin Inhibits Acute Vascular Inflammation through the Activation of Heme Oxygenase-1. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1211223
Modern Language Association (MLA)
Xiao, Yunjun…[et al.]. Curcumin Inhibits Acute Vascular Inflammation through the Activation of Heme Oxygenase-1. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1211223
American Medical Association (AMA)
Xiao, Yunjun& Xia, Junjie& Wu, Shuang& Lv, Ziquan& Huang, Suli& Huang, Haiyan…[et al.]. Curcumin Inhibits Acute Vascular Inflammation through the Activation of Heme Oxygenase-1. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1211223
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211223