Repeated Cycles of Binge-Like Ethanol Intake in Adolescent Female Rats Induce Motor Function Impairment and Oxidative Damage in Motor Cortex and Liver, but Not in Blood
المؤلفون المشاركون
Monteiro, Marta Chagas
Fontes-Júnior, Enéas Andrade
Maia, Cristiane Socorro Ferraz
Fernandes, Luanna Melo Pereira
Lima, Rafael Rodrigues
Gomes, Antônio Rafael Quadros
Santana, Luana N. S.
Paraense, Ricardo Sousa de Oliveira
Silva, Marcia Cristina Freitas
Ribeiro, Carolina Heitmann Mares Azevedo
Crespo-López, Maria Elena
Lopes, Klaylton Sousa
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-09-19
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Moderate ethanol consumption (MEC) is increasing among women.
Alcohol exposure usually starts in adolescence and tends to continue until adulthood.
We aimed to investigate MEC impacts during adolescence until young adulthood of female rats.
Adolescent female Wistar rats received distilled water or ethanol (3 g/kg/day), in a 3 days on-4 days off paradigm (binge drinking) for 1 and 4 consecutive weeks.
We evaluate liver and brain oxidative damage, peripheral oxidative parameters by SOD, catalase, thiol contents, and MDA, and behavioral motor function by open-field, pole, beam-walking, and rotarod tests.
Our results revealed that repeated episodes of binge drinking during adolescence displayed lipid peroxidation in the liver and brain.
Surprisingly, such oxidative damage was not detectable on blood.
Besides, harmful histological effects were observed in the liver, associated to steatosis and loss of parenchymal architecture.
In addition, ethanol intake elicited motor incoordination, bradykinesia, and reduced spontaneous exploratory behavior in female rats.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fernandes, Luanna Melo Pereira& Lopes, Klaylton Sousa& Santana, Luana N. S.& Fontes-Júnior, Enéas Andrade& Ribeiro, Carolina Heitmann Mares Azevedo& Silva, Marcia Cristina Freitas…[et al.]. 2018. Repeated Cycles of Binge-Like Ethanol Intake in Adolescent Female Rats Induce Motor Function Impairment and Oxidative Damage in Motor Cortex and Liver, but Not in Blood. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1211239
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fernandes, Luanna Melo Pereira…[et al.]. Repeated Cycles of Binge-Like Ethanol Intake in Adolescent Female Rats Induce Motor Function Impairment and Oxidative Damage in Motor Cortex and Liver, but Not in Blood. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1211239
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fernandes, Luanna Melo Pereira& Lopes, Klaylton Sousa& Santana, Luana N. S.& Fontes-Júnior, Enéas Andrade& Ribeiro, Carolina Heitmann Mares Azevedo& Silva, Marcia Cristina Freitas…[et al.]. Repeated Cycles of Binge-Like Ethanol Intake in Adolescent Female Rats Induce Motor Function Impairment and Oxidative Damage in Motor Cortex and Liver, but Not in Blood. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1211239
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1211239
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر