Repeated Cycles of Binge-Like Ethanol Intake in Adolescent Female Rats Induce Motor Function Impairment and Oxidative Damage in Motor Cortex and Liver, but Not in Blood
Joint Authors
Monteiro, Marta Chagas
Fontes-Júnior, Enéas Andrade
Maia, Cristiane Socorro Ferraz
Fernandes, Luanna Melo Pereira
Lima, Rafael Rodrigues
Gomes, Antônio Rafael Quadros
Santana, Luana N. S.
Paraense, Ricardo Sousa de Oliveira
Silva, Marcia Cristina Freitas
Ribeiro, Carolina Heitmann Mares Azevedo
Crespo-López, Maria Elena
Lopes, Klaylton Sousa
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-19
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Moderate ethanol consumption (MEC) is increasing among women.
Alcohol exposure usually starts in adolescence and tends to continue until adulthood.
We aimed to investigate MEC impacts during adolescence until young adulthood of female rats.
Adolescent female Wistar rats received distilled water or ethanol (3 g/kg/day), in a 3 days on-4 days off paradigm (binge drinking) for 1 and 4 consecutive weeks.
We evaluate liver and brain oxidative damage, peripheral oxidative parameters by SOD, catalase, thiol contents, and MDA, and behavioral motor function by open-field, pole, beam-walking, and rotarod tests.
Our results revealed that repeated episodes of binge drinking during adolescence displayed lipid peroxidation in the liver and brain.
Surprisingly, such oxidative damage was not detectable on blood.
Besides, harmful histological effects were observed in the liver, associated to steatosis and loss of parenchymal architecture.
In addition, ethanol intake elicited motor incoordination, bradykinesia, and reduced spontaneous exploratory behavior in female rats.
American Psychological Association (APA)
Fernandes, Luanna Melo Pereira& Lopes, Klaylton Sousa& Santana, Luana N. S.& Fontes-Júnior, Enéas Andrade& Ribeiro, Carolina Heitmann Mares Azevedo& Silva, Marcia Cristina Freitas…[et al.]. 2018. Repeated Cycles of Binge-Like Ethanol Intake in Adolescent Female Rats Induce Motor Function Impairment and Oxidative Damage in Motor Cortex and Liver, but Not in Blood. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1211239
Modern Language Association (MLA)
Fernandes, Luanna Melo Pereira…[et al.]. Repeated Cycles of Binge-Like Ethanol Intake in Adolescent Female Rats Induce Motor Function Impairment and Oxidative Damage in Motor Cortex and Liver, but Not in Blood. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1211239
American Medical Association (AMA)
Fernandes, Luanna Melo Pereira& Lopes, Klaylton Sousa& Santana, Luana N. S.& Fontes-Júnior, Enéas Andrade& Ribeiro, Carolina Heitmann Mares Azevedo& Silva, Marcia Cristina Freitas…[et al.]. Repeated Cycles of Binge-Like Ethanol Intake in Adolescent Female Rats Induce Motor Function Impairment and Oxidative Damage in Motor Cortex and Liver, but Not in Blood. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1211239
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211239