Regulation of Tumor Progression by Programmed Necrosis
المؤلفون المشاركون
Lee, Su Yeon
Ju, Min Kyung
Jeon, Hyun Min
Lee, Yig Ji
Kim, Cho Hee
Park, Hye Gyeong
Han, Song Iy
Kang, Ho Sung
Jeong, Eui Kyong
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-28، 28ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-01-31
دولة النشر
مصر
عدد الصفحات
28
التخصصات الرئيسية
الملخص EN
Rapidly growing malignant tumors frequently encounter hypoxia and nutrient (e.g., glucose) deprivation, which occurs because of insufficient blood supply.
This results in necrotic cell death in the core region of solid tumors.
Necrotic cells release their cellular cytoplasmic contents into the extracellular space, such as high mobility group box 1 (HMGB1), which is a nonhistone nuclear protein, but acts as a proinflammatory and tumor-promoting cytokine when released by necrotic cells.
These released molecules recruit immune and inflammatory cells, which exert tumor-promoting activity by inducing angiogenesis, proliferation, and invasion.
Development of a necrotic core in cancer patients is also associated with poor prognosis.
Conventionally, necrosis has been thought of as an unregulated process, unlike programmed cell death processes like apoptosis and autophagy.
Recently, necrosis has been recognized as a programmed cell death, encompassing processes such as oncosis, necroptosis, and others.
Metabolic stress-induced necrosis and its regulatory mechanisms have been poorly investigated until recently.
Snail and Dlx-2, EMT-inducing transcription factors, are responsible for metabolic stress-induced necrosis in tumors.
Snail and Dlx-2 contribute to tumor progression by promoting necrosis and inducing EMT and oncogenic metabolism.
Oncogenic metabolism has been shown to play a role(s) in initiating necrosis.
Here, we discuss the molecular mechanisms underlying metabolic stress-induced programmed necrosis that promote tumor progression and aggressiveness.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lee, Su Yeon& Ju, Min Kyung& Jeon, Hyun Min& Jeong, Eui Kyong& Lee, Yig Ji& Kim, Cho Hee…[et al.]. 2018. Regulation of Tumor Progression by Programmed Necrosis. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-28.
https://search.emarefa.net/detail/BIM-1211257
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lee, Su Yeon…[et al.]. Regulation of Tumor Progression by Programmed Necrosis. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-28.
https://search.emarefa.net/detail/BIM-1211257
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lee, Su Yeon& Ju, Min Kyung& Jeon, Hyun Min& Jeong, Eui Kyong& Lee, Yig Ji& Kim, Cho Hee…[et al.]. Regulation of Tumor Progression by Programmed Necrosis. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-28.
https://search.emarefa.net/detail/BIM-1211257
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1211257
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر