Regulation of Tumor Progression by Programmed Necrosis
Joint Authors
Lee, Su Yeon
Ju, Min Kyung
Jeon, Hyun Min
Lee, Yig Ji
Kim, Cho Hee
Park, Hye Gyeong
Han, Song Iy
Kang, Ho Sung
Jeong, Eui Kyong
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-28, 28 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-31
Country of Publication
Egypt
No. of Pages
28
Main Subjects
Abstract EN
Rapidly growing malignant tumors frequently encounter hypoxia and nutrient (e.g., glucose) deprivation, which occurs because of insufficient blood supply.
This results in necrotic cell death in the core region of solid tumors.
Necrotic cells release their cellular cytoplasmic contents into the extracellular space, such as high mobility group box 1 (HMGB1), which is a nonhistone nuclear protein, but acts as a proinflammatory and tumor-promoting cytokine when released by necrotic cells.
These released molecules recruit immune and inflammatory cells, which exert tumor-promoting activity by inducing angiogenesis, proliferation, and invasion.
Development of a necrotic core in cancer patients is also associated with poor prognosis.
Conventionally, necrosis has been thought of as an unregulated process, unlike programmed cell death processes like apoptosis and autophagy.
Recently, necrosis has been recognized as a programmed cell death, encompassing processes such as oncosis, necroptosis, and others.
Metabolic stress-induced necrosis and its regulatory mechanisms have been poorly investigated until recently.
Snail and Dlx-2, EMT-inducing transcription factors, are responsible for metabolic stress-induced necrosis in tumors.
Snail and Dlx-2 contribute to tumor progression by promoting necrosis and inducing EMT and oncogenic metabolism.
Oncogenic metabolism has been shown to play a role(s) in initiating necrosis.
Here, we discuss the molecular mechanisms underlying metabolic stress-induced programmed necrosis that promote tumor progression and aggressiveness.
American Psychological Association (APA)
Lee, Su Yeon& Ju, Min Kyung& Jeon, Hyun Min& Jeong, Eui Kyong& Lee, Yig Ji& Kim, Cho Hee…[et al.]. 2018. Regulation of Tumor Progression by Programmed Necrosis. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-28.
https://search.emarefa.net/detail/BIM-1211257
Modern Language Association (MLA)
Lee, Su Yeon…[et al.]. Regulation of Tumor Progression by Programmed Necrosis. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-28.
https://search.emarefa.net/detail/BIM-1211257
American Medical Association (AMA)
Lee, Su Yeon& Ju, Min Kyung& Jeon, Hyun Min& Jeong, Eui Kyong& Lee, Yig Ji& Kim, Cho Hee…[et al.]. Regulation of Tumor Progression by Programmed Necrosis. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-28.
https://search.emarefa.net/detail/BIM-1211257
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211257