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Stevia Prevents Acute and Chronic Liver Injury Induced by Carbon Tetrachloride by Blocking Oxidative Stress through Nrf2 Upregulation
المؤلفون المشاركون
Galindo-Gomez, Silvia
Muriel, Pablo
Camacho, Javier
Ramos-Tovar, Erika
Hernández-Aquino, Erika
Casas-Grajales, Sael
Buendia-Montaño, Laura D.
Tsutsumi, Víctor
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-04-19
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
The effect of stevia on liver cirrhosis has not been previously investigated.
In the present study, the antioxidant and anti-inflammatory properties of stevia leaves were studied in male Wistar rats with carbon tetrachloride- (CCl4-) induced acute and chronic liver damage.
Acute and chronic liver damage induced oxidative stress, necrosis, and cholestasis, which were significantly ameliorated by stevia.
Chronic CCl4 treatment resulted in liver cirrhosis, as evidenced by nodules of hepatocytes surrounded by thick bands of collagen and distortion of the hepatic architecture, and stevia significantly prevented these alterations.
Subsequently, the underlying mechanism of action of the plant was analyzed.
Our study for the first time shows that stevia upregulated Nrf2, thereby counteracting oxidative stress, and prevented necrosis and cholestasis through modulation of the main proinflammatory cytokines via NF-κB inhibition.
These multitarget mechanisms led to the prevention of experimental cirrhosis.
Given the reasonable safety profile of stevia, our results indicated that it may be useful for the clinical treatment of acute and chronic liver diseases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ramos-Tovar, Erika& Hernández-Aquino, Erika& Casas-Grajales, Sael& Buendia-Montaño, Laura D.& Galindo-Gomez, Silvia& Camacho, Javier…[et al.]. 2018. Stevia Prevents Acute and Chronic Liver Injury Induced by Carbon Tetrachloride by Blocking Oxidative Stress through Nrf2 Upregulation. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1211311
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ramos-Tovar, Erika…[et al.]. Stevia Prevents Acute and Chronic Liver Injury Induced by Carbon Tetrachloride by Blocking Oxidative Stress through Nrf2 Upregulation. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1211311
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ramos-Tovar, Erika& Hernández-Aquino, Erika& Casas-Grajales, Sael& Buendia-Montaño, Laura D.& Galindo-Gomez, Silvia& Camacho, Javier…[et al.]. Stevia Prevents Acute and Chronic Liver Injury Induced by Carbon Tetrachloride by Blocking Oxidative Stress through Nrf2 Upregulation. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1211311
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1211311
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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