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Stevia Prevents Acute and Chronic Liver Injury Induced by Carbon Tetrachloride by Blocking Oxidative Stress through Nrf2 Upregulation
Joint Authors
Galindo-Gomez, Silvia
Muriel, Pablo
Camacho, Javier
Ramos-Tovar, Erika
Hernández-Aquino, Erika
Casas-Grajales, Sael
Buendia-Montaño, Laura D.
Tsutsumi, Víctor
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-19
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The effect of stevia on liver cirrhosis has not been previously investigated.
In the present study, the antioxidant and anti-inflammatory properties of stevia leaves were studied in male Wistar rats with carbon tetrachloride- (CCl4-) induced acute and chronic liver damage.
Acute and chronic liver damage induced oxidative stress, necrosis, and cholestasis, which were significantly ameliorated by stevia.
Chronic CCl4 treatment resulted in liver cirrhosis, as evidenced by nodules of hepatocytes surrounded by thick bands of collagen and distortion of the hepatic architecture, and stevia significantly prevented these alterations.
Subsequently, the underlying mechanism of action of the plant was analyzed.
Our study for the first time shows that stevia upregulated Nrf2, thereby counteracting oxidative stress, and prevented necrosis and cholestasis through modulation of the main proinflammatory cytokines via NF-κB inhibition.
These multitarget mechanisms led to the prevention of experimental cirrhosis.
Given the reasonable safety profile of stevia, our results indicated that it may be useful for the clinical treatment of acute and chronic liver diseases.
American Psychological Association (APA)
Ramos-Tovar, Erika& Hernández-Aquino, Erika& Casas-Grajales, Sael& Buendia-Montaño, Laura D.& Galindo-Gomez, Silvia& Camacho, Javier…[et al.]. 2018. Stevia Prevents Acute and Chronic Liver Injury Induced by Carbon Tetrachloride by Blocking Oxidative Stress through Nrf2 Upregulation. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1211311
Modern Language Association (MLA)
Ramos-Tovar, Erika…[et al.]. Stevia Prevents Acute and Chronic Liver Injury Induced by Carbon Tetrachloride by Blocking Oxidative Stress through Nrf2 Upregulation. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1211311
American Medical Association (AMA)
Ramos-Tovar, Erika& Hernández-Aquino, Erika& Casas-Grajales, Sael& Buendia-Montaño, Laura D.& Galindo-Gomez, Silvia& Camacho, Javier…[et al.]. Stevia Prevents Acute and Chronic Liver Injury Induced by Carbon Tetrachloride by Blocking Oxidative Stress through Nrf2 Upregulation. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1211311
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211311