Increase and Redistribution of Sex Hormone Receptors in Premenopausal Women Are Associated with Varicose Vein Remodelling
المؤلفون المشاركون
Ortega, Miguel A
Asúnsolo, Ángel
Sainz, Felipe
Buján, Julia
García-Honduvilla, Natalio
Leal, Javier
Lopez-Hervas, Pedro
Pascual, Gemma
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-09-03
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
In chronic venous insufficiency of the lower limbs, data show that the clinical manifestation is varicose veins (VVs), and VV epidemiology suggests that sex hormones directly influence disease development through intracellular receptors.
This study aimed to determine the presence and localization of oestrogen receptors (ERs), progesterone receptors (PRs), and androgen receptors (ARs) in both healthy and VV wall cells and their relationship with gender.
In this study, samples from patients without a history of venous disease (CV) (n=18) and with VV (n=40) were used.
The samples were divided by gender: CV women (CVw) = 6, CV men (CVm) = 12, VV women (VVw) = 25, and VV men (VVm) = 15.
RT-qPCR and immunohistochemical techniques were performed, and increased ER and PR protein expression was found in VVw in all tunica layers.
ARs were localized to the adventitial layer in the CV and were found in the neointima in VVs.
mRNA expression was increased for ER and PR in VVw.
AR gene expression was significantly decreased in VVm.
The increase in the number of these receptors and their redistribution through the wall reinforces the role of sex hormones in varicose vein development.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
García-Honduvilla, Natalio& Asúnsolo, Ángel& Ortega, Miguel A& Sainz, Felipe& Leal, Javier& Lopez-Hervas, Pedro…[et al.]. 2018. Increase and Redistribution of Sex Hormone Receptors in Premenopausal Women Are Associated with Varicose Vein Remodelling. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1211337
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
García-Honduvilla, Natalio…[et al.]. Increase and Redistribution of Sex Hormone Receptors in Premenopausal Women Are Associated with Varicose Vein Remodelling. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1211337
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
García-Honduvilla, Natalio& Asúnsolo, Ángel& Ortega, Miguel A& Sainz, Felipe& Leal, Javier& Lopez-Hervas, Pedro…[et al.]. Increase and Redistribution of Sex Hormone Receptors in Premenopausal Women Are Associated with Varicose Vein Remodelling. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1211337
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1211337
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر