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Increase and Redistribution of Sex Hormone Receptors in Premenopausal Women Are Associated with Varicose Vein Remodelling
Joint Authors
Ortega, Miguel A
Asúnsolo, Ángel
Sainz, Felipe
Buján, Julia
García-Honduvilla, Natalio
Leal, Javier
Lopez-Hervas, Pedro
Pascual, Gemma
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
In chronic venous insufficiency of the lower limbs, data show that the clinical manifestation is varicose veins (VVs), and VV epidemiology suggests that sex hormones directly influence disease development through intracellular receptors.
This study aimed to determine the presence and localization of oestrogen receptors (ERs), progesterone receptors (PRs), and androgen receptors (ARs) in both healthy and VV wall cells and their relationship with gender.
In this study, samples from patients without a history of venous disease (CV) (n=18) and with VV (n=40) were used.
The samples were divided by gender: CV women (CVw) = 6, CV men (CVm) = 12, VV women (VVw) = 25, and VV men (VVm) = 15.
RT-qPCR and immunohistochemical techniques were performed, and increased ER and PR protein expression was found in VVw in all tunica layers.
ARs were localized to the adventitial layer in the CV and were found in the neointima in VVs.
mRNA expression was increased for ER and PR in VVw.
AR gene expression was significantly decreased in VVm.
The increase in the number of these receptors and their redistribution through the wall reinforces the role of sex hormones in varicose vein development.
American Psychological Association (APA)
García-Honduvilla, Natalio& Asúnsolo, Ángel& Ortega, Miguel A& Sainz, Felipe& Leal, Javier& Lopez-Hervas, Pedro…[et al.]. 2018. Increase and Redistribution of Sex Hormone Receptors in Premenopausal Women Are Associated with Varicose Vein Remodelling. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1211337
Modern Language Association (MLA)
García-Honduvilla, Natalio…[et al.]. Increase and Redistribution of Sex Hormone Receptors in Premenopausal Women Are Associated with Varicose Vein Remodelling. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1211337
American Medical Association (AMA)
García-Honduvilla, Natalio& Asúnsolo, Ángel& Ortega, Miguel A& Sainz, Felipe& Leal, Javier& Lopez-Hervas, Pedro…[et al.]. Increase and Redistribution of Sex Hormone Receptors in Premenopausal Women Are Associated with Varicose Vein Remodelling. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1211337
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211337