The Ratio of Plasma and Urinary 8-oxo-Gsn Could Be a Novel Evaluation Index for Patients with Chronic Kidney Disease
المؤلفون المشاركون
Cai, Jian-Ping
Tan, Hongling
Lengnan, Xu
Ban, Zhao
Yonghui, Mao
Weng, Qinghua
Li, Xiang-Yu
Nie, Jing-Jing
Hu, Ji-Hong
Chen, Zhe
Zuo, Ming-Zhang
Ito, Sadayoshi
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-01-17
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Nucleic acid oxidation plays an important role in the pathophysiology progress of a variety of diseases.
8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxo-dGsn) and 8-oxo-7,8-dihydroguanosine (8-oxo-Gsn), which originate from DNA and RNA oxidation, were the most widely used indicators for oxidative stress.
The study investigated the relation between 8-oxo-dGsn, 8-oxo-Gsn, and CKD.
146 patients with CKD were divided into five disease stages, and their fasting blood and morning urine were collected.
The levels of 8-oxo-dGsn and 8-oxo-Gsn in plasma and urine were quantified by LC-MS/MS.
The ratio of urinary 8-oxo-Gsn to creatinine increased from stages 1 to 4 corresponding to the increased severity of CKD, but it decreased in stage 5.
And plasma 8-oxo-Gsn gradually increased with the decline of renal function.
In particular, the increased ratio of plasma and urine 8-oxo-Gsn in stage 5 exceeded the concentration of creatinine.
This trend was similar to the estimated glomerular filtration rate (eGFR), which indicates that 8-oxo-Gsn could be an appropriate indicator for renal function.
Our finding indicates that as the disease progresses, RNA oxidation is increased.
The significant increase in the ratio of plasma and urinary 8-oxo-Gsn is a novel evaluation index of end-stage renal disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yonghui, Mao& Lengnan, Xu& Weng, Qinghua& Li, Xiang-Yu& Ban, Zhao& Nie, Jing-Jing…[et al.]. 2018. The Ratio of Plasma and Urinary 8-oxo-Gsn Could Be a Novel Evaluation Index for Patients with Chronic Kidney Disease. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1211405
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yonghui, Mao…[et al.]. The Ratio of Plasma and Urinary 8-oxo-Gsn Could Be a Novel Evaluation Index for Patients with Chronic Kidney Disease. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1211405
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yonghui, Mao& Lengnan, Xu& Weng, Qinghua& Li, Xiang-Yu& Ban, Zhao& Nie, Jing-Jing…[et al.]. The Ratio of Plasma and Urinary 8-oxo-Gsn Could Be a Novel Evaluation Index for Patients with Chronic Kidney Disease. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1211405
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1211405
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر