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The Ratio of Plasma and Urinary 8-oxo-Gsn Could Be a Novel Evaluation Index for Patients with Chronic Kidney Disease
Joint Authors
Cai, Jian-Ping
Tan, Hongling
Lengnan, Xu
Ban, Zhao
Yonghui, Mao
Weng, Qinghua
Li, Xiang-Yu
Nie, Jing-Jing
Hu, Ji-Hong
Chen, Zhe
Zuo, Ming-Zhang
Ito, Sadayoshi
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Nucleic acid oxidation plays an important role in the pathophysiology progress of a variety of diseases.
8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxo-dGsn) and 8-oxo-7,8-dihydroguanosine (8-oxo-Gsn), which originate from DNA and RNA oxidation, were the most widely used indicators for oxidative stress.
The study investigated the relation between 8-oxo-dGsn, 8-oxo-Gsn, and CKD.
146 patients with CKD were divided into five disease stages, and their fasting blood and morning urine were collected.
The levels of 8-oxo-dGsn and 8-oxo-Gsn in plasma and urine were quantified by LC-MS/MS.
The ratio of urinary 8-oxo-Gsn to creatinine increased from stages 1 to 4 corresponding to the increased severity of CKD, but it decreased in stage 5.
And plasma 8-oxo-Gsn gradually increased with the decline of renal function.
In particular, the increased ratio of plasma and urine 8-oxo-Gsn in stage 5 exceeded the concentration of creatinine.
This trend was similar to the estimated glomerular filtration rate (eGFR), which indicates that 8-oxo-Gsn could be an appropriate indicator for renal function.
Our finding indicates that as the disease progresses, RNA oxidation is increased.
The significant increase in the ratio of plasma and urinary 8-oxo-Gsn is a novel evaluation index of end-stage renal disease.
American Psychological Association (APA)
Yonghui, Mao& Lengnan, Xu& Weng, Qinghua& Li, Xiang-Yu& Ban, Zhao& Nie, Jing-Jing…[et al.]. 2018. The Ratio of Plasma and Urinary 8-oxo-Gsn Could Be a Novel Evaluation Index for Patients with Chronic Kidney Disease. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1211405
Modern Language Association (MLA)
Yonghui, Mao…[et al.]. The Ratio of Plasma and Urinary 8-oxo-Gsn Could Be a Novel Evaluation Index for Patients with Chronic Kidney Disease. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1211405
American Medical Association (AMA)
Yonghui, Mao& Lengnan, Xu& Weng, Qinghua& Li, Xiang-Yu& Ban, Zhao& Nie, Jing-Jing…[et al.]. The Ratio of Plasma and Urinary 8-oxo-Gsn Could Be a Novel Evaluation Index for Patients with Chronic Kidney Disease. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1211405
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211405