Cellular Stresses and Stress Responses in the Pathogenesis of Insulin Resistance
المؤلف
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-27، 27ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-07-09
دولة النشر
مصر
عدد الصفحات
27
التخصصات الرئيسية
الملخص EN
Insulin resistance (IR), a key component of the metabolic syndrome, precedes the development of diabetes, cardiovascular disease, and Alzheimer’s disease.
Its etiological pathways are not well defined, although many contributory mechanisms have been established.
This article summarizes such mechanisms into the hypothesis that factors like nutrient overload, physical inactivity, hypoxia, psychological stress, and environmental pollutants induce a network of cellular stresses, stress responses, and stress response dysregulations that jointly inhibit insulin signaling in insulin target cells including endothelial cells, hepatocytes, myocytes, hypothalamic neurons, and adipocytes.
The insulin resistance-inducing cellular stresses include oxidative, nitrosative, carbonyl/electrophilic, genotoxic, and endoplasmic reticulum stresses; the stress responses include the ubiquitin-proteasome pathway, the DNA damage response, the unfolded protein response, apoptosis, inflammasome activation, and pyroptosis, while the dysregulated responses include the heat shock response, autophagy, and nuclear factor erythroid-2-related factor 2 signaling.
Insulin target cells also produce metabolites that exacerbate cellular stress generation both locally and systemically, partly through recruitment and activation of myeloid cells which sustain a state of chronic inflammation.
Thus, insulin resistance may be prevented or attenuated by multiple approaches targeting the different cellular stresses and stress responses.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Onyango, Arnold N.. 2018. Cellular Stresses and Stress Responses in the Pathogenesis of Insulin Resistance. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-27.
https://search.emarefa.net/detail/BIM-1211421
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Onyango, Arnold N.. Cellular Stresses and Stress Responses in the Pathogenesis of Insulin Resistance. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-27.
https://search.emarefa.net/detail/BIM-1211421
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Onyango, Arnold N.. Cellular Stresses and Stress Responses in the Pathogenesis of Insulin Resistance. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-27.
https://search.emarefa.net/detail/BIM-1211421
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1211421
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر