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2-Methoxyestradiol Attenuates Testosterone-Induced Benign Prostate Hyperplasia in Rats through Inhibition of HIF-1αTGF-βSmad2 Axis
المؤلفون المشاركون
Eid, Basma G.
Neamatallah, Thikrayat
Abdel-Naim, Ashraf B.
Esmat, Ahmed
Alamoudi, Abdulmohsin J.
Abd El-Aziz, Gamal S.
Ashour, Osama M.
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-08-01
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Benign prostatic hyperplasia (BPH) is a common disorder in the male population.
2-Methoxyestradiol (2ME) is an end metabolite of estrogens with pleiotropic pharmacological properties.
This study aimed to explore the potential ameliorative effects of 2ME against testosterone-induced BPH in rats.
2-Methoxyestradiol (50 and 100 mg/kg, dissolved in DMSO) prevented the rise in prostatic index and weight in comparison to testosterone-alone-treated animals for 2 weeks.
Histological examination indicated that 2ME ameliorated pathological changes in prostate architecture.
This was confirmed by the ability of 2ME to decrease the glandular epithelial height when compared to the testosterone group.
Also, 2ME improved testosterone-induced oxidative stress as it inhibited the rise in lipid peroxide content and the exhaustion of superoxide dismutase (SOD) activity.
The beneficial effects of 2ME against the development of BPH were substantiated by assessing proliferation markers, preventing the rise in cyclin D1 protein expression and enhancing Bax/Bcl2 mRNA ratio.
It significantly reduced prostate content of tumor necrosis factor α (TNF-α), interleukin-1β (IL-1β), nuclear factor κB (NF-κB), and transforming growth factor β (TGF-β).
In addition, 2ME reduced hypoxia-inducible factor 1-α (HIF-1α) and phospho-Smad2 (p-Smad2) protein expression compared to the testosterone group.
In conclusion, 2ME attenuates experimentally induced BPH by testosterone in rats through, at least partly, inhibition of HIF-1α/TGF-β/Smad2 axis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abdel-Naim, Ashraf B.& Neamatallah, Thikrayat& Eid, Basma G.& Esmat, Ahmed& Alamoudi, Abdulmohsin J.& Abd El-Aziz, Gamal S.…[et al.]. 2018. 2-Methoxyestradiol Attenuates Testosterone-Induced Benign Prostate Hyperplasia in Rats through Inhibition of HIF-1αTGF-βSmad2 Axis. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1211425
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abdel-Naim, Ashraf B.…[et al.]. 2-Methoxyestradiol Attenuates Testosterone-Induced Benign Prostate Hyperplasia in Rats through Inhibition of HIF-1αTGF-βSmad2 Axis. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1211425
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abdel-Naim, Ashraf B.& Neamatallah, Thikrayat& Eid, Basma G.& Esmat, Ahmed& Alamoudi, Abdulmohsin J.& Abd El-Aziz, Gamal S.…[et al.]. 2-Methoxyestradiol Attenuates Testosterone-Induced Benign Prostate Hyperplasia in Rats through Inhibition of HIF-1αTGF-βSmad2 Axis. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1211425
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1211425
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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