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2-Methoxyestradiol Attenuates Testosterone-Induced Benign Prostate Hyperplasia in Rats through Inhibition of HIF-1αTGF-βSmad2 Axis
Joint Authors
Eid, Basma G.
Neamatallah, Thikrayat
Abdel-Naim, Ashraf B.
Esmat, Ahmed
Alamoudi, Abdulmohsin J.
Abd El-Aziz, Gamal S.
Ashour, Osama M.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-01
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Benign prostatic hyperplasia (BPH) is a common disorder in the male population.
2-Methoxyestradiol (2ME) is an end metabolite of estrogens with pleiotropic pharmacological properties.
This study aimed to explore the potential ameliorative effects of 2ME against testosterone-induced BPH in rats.
2-Methoxyestradiol (50 and 100 mg/kg, dissolved in DMSO) prevented the rise in prostatic index and weight in comparison to testosterone-alone-treated animals for 2 weeks.
Histological examination indicated that 2ME ameliorated pathological changes in prostate architecture.
This was confirmed by the ability of 2ME to decrease the glandular epithelial height when compared to the testosterone group.
Also, 2ME improved testosterone-induced oxidative stress as it inhibited the rise in lipid peroxide content and the exhaustion of superoxide dismutase (SOD) activity.
The beneficial effects of 2ME against the development of BPH were substantiated by assessing proliferation markers, preventing the rise in cyclin D1 protein expression and enhancing Bax/Bcl2 mRNA ratio.
It significantly reduced prostate content of tumor necrosis factor α (TNF-α), interleukin-1β (IL-1β), nuclear factor κB (NF-κB), and transforming growth factor β (TGF-β).
In addition, 2ME reduced hypoxia-inducible factor 1-α (HIF-1α) and phospho-Smad2 (p-Smad2) protein expression compared to the testosterone group.
In conclusion, 2ME attenuates experimentally induced BPH by testosterone in rats through, at least partly, inhibition of HIF-1α/TGF-β/Smad2 axis.
American Psychological Association (APA)
Abdel-Naim, Ashraf B.& Neamatallah, Thikrayat& Eid, Basma G.& Esmat, Ahmed& Alamoudi, Abdulmohsin J.& Abd El-Aziz, Gamal S.…[et al.]. 2018. 2-Methoxyestradiol Attenuates Testosterone-Induced Benign Prostate Hyperplasia in Rats through Inhibition of HIF-1αTGF-βSmad2 Axis. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1211425
Modern Language Association (MLA)
Abdel-Naim, Ashraf B.…[et al.]. 2-Methoxyestradiol Attenuates Testosterone-Induced Benign Prostate Hyperplasia in Rats through Inhibition of HIF-1αTGF-βSmad2 Axis. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1211425
American Medical Association (AMA)
Abdel-Naim, Ashraf B.& Neamatallah, Thikrayat& Eid, Basma G.& Esmat, Ahmed& Alamoudi, Abdulmohsin J.& Abd El-Aziz, Gamal S.…[et al.]. 2-Methoxyestradiol Attenuates Testosterone-Induced Benign Prostate Hyperplasia in Rats through Inhibition of HIF-1αTGF-βSmad2 Axis. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1211425
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211425