![](/images/graphics-bg.png)
Possible Involvement of Mitochondrial Dysfunction and Oxidative Stress in a Cellular Model of NAFLD Progression Induced by Benzo[a]pyreneEthanol CoExposure
المؤلفون المشاركون
Bucher, Simon
Le Guillou, Dounia
Allard, Julien
Pinon, Grégory
Begriche, Karima
Tête, Arnaud
Sergent, Odile
Lagadic-Gossmann, Dominique
Fromenty, Bernard
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-18، 18ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-07-26
دولة النشر
مصر
عدد الصفحات
18
التخصصات الرئيسية
الملخص EN
Exposure to xenobiotics could favor the transition of nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis in obese patients.
Recently, we showed in different models of NAFL that benzo[a]pyrene (B[a]P) and ethanol coexposure induced a steatohepatitis-like state.
One model was HepaRG cells incubated with stearate and oleate for 2 weeks.
In the present study, we wished to determine in this model whether mitochondrial dysfunction and reactive oxygen species (ROS) overproduction could be involved in the occurrence of this steatohepatitis-like state.
CRISPR/Cas9-modified cells were also used to specify the role of aryl hydrocarbon receptor (AhR), which is potently activated by B[a]P.
Thus, nonsteatotic and steatotic HepaRG cells were treated with B[a]P, ethanol, or both molecules for 2 weeks.
B[a]P/ethanol coexposure reduced mitochondrial respiratory chain activity, mitochondrial respiration, and mitochondrial DNA levels and induced ROS overproduction in steatotic HepaRG cells.
These deleterious effects were less marked or absent in steatotic cells treated with B[a]P alone or ethanol alone and in nonsteatotic cells treated with B[a]P/ethanol.
Our study also disclosed that B[a]P/ethanol-induced impairment of mitochondrial respiration was dependent on AhR activation.
Hence, mitochondrial dysfunction and ROS generation could explain the occurrence of a steatohepatitis-like state in steatotic HepaRG cells exposed to B[a]P and ethanol.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bucher, Simon& Le Guillou, Dounia& Allard, Julien& Pinon, Grégory& Begriche, Karima& Tête, Arnaud…[et al.]. 2018. Possible Involvement of Mitochondrial Dysfunction and Oxidative Stress in a Cellular Model of NAFLD Progression Induced by Benzo[a]pyreneEthanol CoExposure. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-18.
https://search.emarefa.net/detail/BIM-1211428
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bucher, Simon…[et al.]. Possible Involvement of Mitochondrial Dysfunction and Oxidative Stress in a Cellular Model of NAFLD Progression Induced by Benzo[a]pyreneEthanol CoExposure. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-18.
https://search.emarefa.net/detail/BIM-1211428
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bucher, Simon& Le Guillou, Dounia& Allard, Julien& Pinon, Grégory& Begriche, Karima& Tête, Arnaud…[et al.]. Possible Involvement of Mitochondrial Dysfunction and Oxidative Stress in a Cellular Model of NAFLD Progression Induced by Benzo[a]pyreneEthanol CoExposure. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-18.
https://search.emarefa.net/detail/BIM-1211428
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1211428
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)